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EC number: 604-669-5 | CAS number: 149021-58-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
To assess the long term effects on aquatic invertebrates two studies with ethyl acrylate and n-butyl acrylate were conducted. The most sensitive NOEC of 0.14 mg/L (reproduction) was obtained for Daphnia magna after 21 days of exposure to n-butyl acrylate.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.14 mg/L
Additional information
No experimental data on 2-propylheptyl acrylate are available. Therefore, the long term effects on aquatic invertebrates were assessed by experimental data on the structural analogue ethyl acrylate (CAS 140-88-5) and n-butyl acrylate (CAS 141-32-2).
The 21-day chronic study with ethyl acrylate in Daphnia magna was conducted under flow-through conditions according to EPA OTS 797.1330 (BAMM, 1997). Four replicate test chambers per control and each test concentration were grouped and assigned to the mean measured treatment concentrations 0.19, 0.45, 0.73, 1.7, and 3.2 mg/L. Initially, there were 10 daphnids per replicate chamber. Daphnids in all concentrations were observed once daily for immobility and other abnormal effects such as surfacing, trialing extraneous material quiescence, and /or tending to the bottom of the test chamber. Survival of Daphnia Magna was shown to be significantly affected in the 0.73, 1.7 and 3.2 mg/L mean measured test concentrations as compared to the control. At 21 days three categories of response variables were analyzed: survival, reproduction and growth. Effect concentrations based on measured values were as follows:
EC50 (immobility/mortality) = 0.5 mg/L
NOEC (reproduction) = 0.19 mg/L
LOEC (reproduction) = 0.45 mg/L
MATC (reproduction) = 0.29 mg/L
For n-butyl acrylate a 21 -day Daphnia magna Reproduction Test was performed under semi-static conditions in accordance with OECD TG 211 and GLP regulations (BASF SE, 2009). 0, 0.1, 0.22, 0.46 and 2.2 mg/L were tested as nominal concentrations based on test substance mass. For each concentration 10 animals were examined in replicates. Significant effects on reproduction and /or growth were observed for test groups > 1.0 mg/L. The effect on reproduction was the most sensitive end point. The data was not sufficient to calculate ECx values for reproduction or growth. No mortality was observed among parent animals over the 21d exposure period (21 d EC0 > 2.2 mg/L). No additional adverse effects or abnormal behaviour were observed in any of the test treatments. Since the measured concentrations deviated markedly from the nominal concentrations, the effect concentration, which is based on the time weighted mean analytically detected concentrations should be preferably used for the evaluation of the test substance. The most sensitive effect values were concerning reproduction:
NOEC (measured, TWA) = 0.136 mg/L
LOEC (measured, TWA) = 0.457 mg/L.
Survival of the parent or young daphnia was not effected, but the growth (body length) of the parent animals:
NOEC (measured, TWA) = 0.457 mg/L
LOEC (measured, TWA) = 1.226 mg/L.
The results in this study are consistent with all validity criteria and the test is valid according to the guidelines of this study. No deviations from test guidelines or other incidents occurred during the course of the reported test which may have influenced the results.
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