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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
March - May 2006
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2006
Report date:
2006

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Version / remarks:
1987
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Test type:
fixed dose procedure
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
480-410-8
EC Name:
-
Cas Number:
13482-23-0
Molecular formula:
Hill formula: C7H12O2 CAS formula: C7H12O2
IUPAC Name:
4-methoxycyclohexan-1-one

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 hours
Doses:
2000 mg/kg bw.
No. of animals per sex per dose:
5 male and 5 female
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
no mortalities occured
Clinical signs:
other:

Any other information on results incl. tables

The following local clinical sign was observed: partial reddening of the test area.


There were no toxicological effects on body weight or body weight development in males. In one female a decrease in body weight gain was observed in the first week.


The necropsies performed at the end of the study revealed no particular findings.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
the test item is of low acute dermal toxicity
Executive summary:

Groups of 5 male and 5 female Wistar rats received a single dermal dose of 2000 mg/kg body weight of the test compound applied semiocclusively for 24 hours.


Based on the present investigations, 4-Methoxycyclohexanone is to be regarded to have the following LD50 values:
LD50 rat, male : > 2000 mg/kg body weight; rat, female : > 2000 mg/kg body weight


So it is regarded as very low toxic after dermal application.