Registration Dossier
Registration Dossier
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EC number: 611-342-0 | CAS number: 55974-25-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD 404) but full details are not available. Therefore the reliability is with restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 7-methoxy-4,4-dimethyl-3,4-dihydro-1H-2-benzopyran-1,3-dione
- EC Number:
- 611-342-0
- Cas Number:
- 55974-25-9
- Molecular formula:
- C12 H12 O4
- IUPAC Name:
- 7-methoxy-4,4-dimethyl-3,4-dihydro-1H-2-benzopyran-1,3-dione
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Isochroman puro
- Physical state: powder
- Lot/batch No.: 01002
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2 - 3 kg
- Diet (e.g. ad libitum): Conventional feeding
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 - 23
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12 :12
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- clipped
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 6 cm²
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: all animals
- Time point:
- other: 4 , 24, 48, 72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal: all animals
- Time point:
- other: 4 , 24, 48, 72 h
- Score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- In conclusion, according to the Globally Harmonized Classification System, Isochroman puro was non-irritating / non-corrosive to the skin of the
rabbits under the conditions of the study. - Executive summary:
Isochroman puro does not cause any edema nor erythema which could be detected after the 4 hours of contact of the sample within the test experimentation conditions.
Therefore Isochroman puro is a non corrosive and non irritant product by skin contact.
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