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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The substance is corrosive to skin and therefore need not be tested for acute toxicity.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is classified as corrosive to the skin
Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is classified as corrosive to the skin
Sex:
male/female
Dose descriptor:
LC50
Effect level:
945 mg/m³ air
Based on:
other: BCl3, by transcribing the LC50 for HCl.
Exp. duration:
4 h
Remarks on result:
other: See below for transcription procedure.

Hydrogen chloride is a corrosive substance and will therefore dominate in the degradation category, see Section 13, the acute toxicity, compared to the other degradation product boric acid.

Known data for hydrogen chloride:

The LC50,30min values of 4701 ppm (7051mg/m3) and 5666 ppm (8500 mg/m3) have been determined for the gas and aerosol respectively, in rats and mice. The principal effects seen in acute toxicity studies were irritation of the eyes, upper respiratory tract and exposed areas of skin. When inhaled at high concentrations, the gas caused necrosis of the epithelial lining of the nasotracheal passages as well as alveolar emphysema, atelectasis and lung oedema.

7051 mg HCl/m³ is transcribed to 7557 mg BCl3/m³. Applying Haber's rule: LC50,4h = 945 mg BCl3/m³.

Interpretation of results:
other: corrosive
Conclusions:
BCl3 is a corrosive gas and need not be investigated for acute toxicity.
The LC50,4h is estimated to 945 mg BCl3/m³, by transcribing the LC50 for HCL, based on the degradation category approach.
Executive summary:

- According to column 2 of Annex VII respectively VIII of REACH, "the study/ies do(es) not generally need to be conducted if the substance is classified as corrosive to the skin ...". BCl3 is classified as corrosive.

- BCl3 is classified in the CLP regulation as (Fatal if inhaled).

The LC50,4h is estimated to 945 mg BCl3/m³ (194 ppm), by transcribing the LC50 for HCL, based on the degradation category approach. This confirms the classification in Acute Tox. 2, H330.

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is classified as corrosive to the skin
the study does not need to be conducted because inhalation of the substance is likely
Interpretation of results:
other: corrosive
Conclusions:
BCl3 is classified as corrosive.
Executive summary:

According to column 2 of Annex VII respectively VIII of REACH, "the study/ies do(es) not generally need to be conducted if the substance is classified as corrosive to the skin ...". BCl3 is classified as corrosive. The likely route of exposure is inhalation.

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Acute oral toxicity:

- According to column 2 of Annex VII respectively VIII of REACH, "the study/ies do(es) not generally need to be conducted if the substance is classified as corrosive to the skin ...". BCl3 is classified as Skin Corr. 1B, H314 on Annex VI of the CLP regulation 1272/2008.

- According to REACH, Annex XI, section 2, 'Testing is technically not possible'. Justification: BCl3 is a gas and can not be dosed orally.

- BCl3 is classified on Annex VI of the CLP regulation as Acute Tox. 2, H300.

Acute inhalation toxicity:

- According to column 2 of Annex VII respectively VIII of REACH, "the study/ies do(es) not generally need to be conducted if the substance is classified as corrosive to the skin ...". BCl3 is classified on Annex VI of the CLP relulation 1272/2008 as Skin Corr. 1B, H314.

- BCl3 is classified on Annev VI of the CLP regulation 1272/2008 as Acute Tox. 2 *, H330 (Fatal if inhaled).

Acute dermal toxicity:

- According to column 2 of Annex VII respectively VIII of REACH, "the study/ies do(es) not generally need to be conducted if the substance is classified as corrosive to the skin ...". BCl3 is classified on Annex VI of the CLP regulation 1272/2008 as Skin Corr. 1B, H314. The likely route of exposure is inhalation.

Justification for selection of acute toxicity – inhalation endpoint

A transcription of the LC50 of the degradation product HCl to the source substance BCl3 in the category approach is performed.

The other study by Vernot 1977 is poorly described and does not seem to be reliable.

Justification for classification or non-classification

BCl3 is classified as Acute Tox. 2, H330 (inhalation) and Acute Tox. 2, H300 (oral) according to Annex VI of the CLP regulation 1272/2008.