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Diss Factsheets
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EC number: 232-156-2 | CAS number: 7789-29-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Older, non-GLP published study.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Age sensitivity of the body to fluoride ions in the air.
- Author:
- Sadilova MS et al
- Year:
- 1 974
- Bibliographic source:
- Gig. Sanit. 1974; 12:33-36
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Repeated exposure inhalation toxicity in rats
- GLP compliance:
- no
- Remarks:
- : older published study, pre-dates GLP
- Limit test:
- no
Test material
- Reference substance name:
- Hydrogen fluoride
- EC Number:
- 231-634-8
- EC Name:
- Hydrogen fluoride
- Cas Number:
- 7664-39-3
- IUPAC Name:
- fluoride
- Details on test material:
- No further details
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Female rats of various ages were used in this test. No environmental conditions are given.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Exposure of female rats of various age to 1 mg HF/m3 for 1 month, 6 hours per day.
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- There was no analytical determination of concentration. The concentration stated is nominal.
- Duration of treatment / exposure:
- 1 month
- Frequency of treatment:
- 6 hours per day.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1 mg/m3
Basis:
nominal conc.
- No. of animals per sex per dose:
- The number of animals is not stated.
- Control animals:
- not specified
- Details on study design:
- Exposure of female rats of various age to 1 mg HF/m3 for 1 month, 6 hours per day.
Examinations
- Sacrifice and pathology:
- Examination of the lungs,airways, bones and teeth at the end of the exposure.
- Other examinations:
- No further examination
- Statistics:
- None
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- not examined
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Details on results:
- Exposure of female rats of various age to 1 mg HF/m3 for 1 months, 6 hr/d resulted in damage to the dental enamel. This effect was especially seen in young animals and in animals of 17.6 to 18.6 months of age. The respiratory organs of the young animals showed atrophy and local oedema of the bronchial mucosa. In the older animals, the lungs showed peribronchial hyperplasia. In animals of about 12 months the formation of irregular shaped cavities in their bones
Effect levels
- Dose descriptor:
- LOAEC
- Effect level:
- 1 mg/m³ air
- Sex:
- female
- Basis for effect level:
- other: Effects on the teeth, bones and respiratory tract were seen at the single concentration of HF investigated in this study.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
See above
Applicant's summary and conclusion
- Conclusions:
- Exposure to HF vapour for one month resulted in effects on the teeth, bones and respiratory tract.
- Executive summary:
Exposure of female rats of various ages to 1 mg HF/m3 for 1 months, 6 hr/d resulted in damage to the dental enamel. This effect was most marked in young animals and in animals of 17.6-18.6 months of age. The respiratory organs of the young animals showed atrophy and local oedema of the bronchial mucosa. In older animals, the lungs showed peribronchiqal hyperplasia. In animals of about 12 months old the formation of irregular shaped cavities in bones was noted.
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