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EC number: 204-493-5 | CAS number: 121-69-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity oral
The acute toxicity by oral route was examined on 5 non-fasted, male Carworth-Wistar rats by gastric intubation. In this study, lethal dose (LD50) concentration was found to be 1348 mg/kg.
Acute toxicity: inhalation
Lowest lethal concentration (LCLo) by inhalation route of N,N-dimethylaniline to rat was found to be 250 mg/m3 indicating that the chemical is moderately toxic.
Acute toxicity: dermal
The acute toxicity by dermal route was examined on the groups of 4 male New Zealand rabbits. All animals were tested using a technique similar to the Draize method. The dose was placed on clipped skin and retained beneath an impervious plastic film for 24 hours. The lethal dose (LD50) of N,N-dimethylaniline (LD50) was found to be 1692 mg/kg body weight.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Compound was administered by gastric intubation to groups of 5 non-fasted, male Carworth-Wistar rats, 90 to 120 gm weight. The LD50 value was determined using Thompson method.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- weight: 90 to 120 gm
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- Compound was administered by gastric intubation to groups of 5 non-fasted, male Carworth-Wistar rats, 90 to 120 gm weight. The LD50 value was determined using Thompson method.
- Doses:
- no data
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 348 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Other details not available
- Mortality:
- The LD50 value was reported as 1.41 mL/kg, and was determined using Thompson method. (Conversion of 1.41 mL/kg to mg/kg using specific gravity of 0.956 at 20/4°C). No fiducial range was calculated since no dose resulted in partial mortality.
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute toxicity by oral route was examined on 5 non-fasted, male Carworth-Wistar rats by gastric intubation. In this study, lethal dose (LD50) concentration was found to be 1348 mg/kg.
- Executive summary:
- The acute toxicity by oral route was examined on 5 non-fasted, male Carworth-Wistar rats by gastric intubation. In this study, lethal dose (LD50) concentration was found to be 1348 mg/kg. This value indicates that, N,N-dimethylaniline exhibits acute toxicity by the oral route and will be classified as Acute oral category 4.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 348 mg/kg bw
- Quality of whole database:
- The data is of K2 level
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Standard acute method
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- not reported
- No. of animals per sex per dose:
- not reported
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LCLo
- Effect level:
- 250 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: Other details not available
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Lowest lethal concentration (LCLo) of N,N-dimethylaniline to rat by inhalation route was found to be 250 mg/m³ indicating that the chemical is moderately toxic.
- Executive summary:
Lowest lethal concentration (LCLo) of N,N-dimethylaniline to rat by inhalation route was found to be 250 mg/m³ indicating that the chemical is moderately toxic.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Value:
- 250 mg/m³ air
- Quality of whole database:
- The data is of K2 level
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Groups of 4 male New Zealand rabbits (weight 2.5 to 3.5 kg) were tested using a technique similar to the Draize method. The dose was placed on clipped skin and retained beneath an impervious plastic film for 24 hours.
- GLP compliance:
- not specified
- Test type:
- other: technique similar to the Draize method.
- Species:
- rabbit
- Strain:
- other: New Zealand
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- New Zealand rabbits (weight 2.5 to 3.5 kg)
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- Groups of 4 male albino New Zealand rabbits (weight 2.5 to 3.5 kg) were tested using a technique similar to the Draize method. The dose was placed on clipped skin and retained beneath an impervious plastic film for 24 hours.
- Duration of exposure:
- 24 hrs.
- Doses:
- no data
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 692 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Other details not available
- Mortality:
- The LD50 was reported as 1.77 mL/kg, with a standard deviation range of 1.09 to 2.86 mL/kg.
Conversion to mg/kg used the specific gravity of 0.956 at 20/4°C. - Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute toxicity by dermal route was examined on the groups of 4 male New Zealand rabbits. All animals were tested using a technique similar to the Draize method. The dose was placed on clipped skin and retained beneath an impervious plastic film for 24 hours. In this study, lethal dose (LD50) concentration was found to be 1692 mg/kg.
- Executive summary:
The acute toxicity by dermal route was examined on the groups of 4 male New Zealand rabbits. All animals were tested using a technique similar to the Draize method. The dose was placed on clipped skin and retained beneath an impervious plastic film for 24 hours.
The lethal dose (LD50) was found to be 1.77 mL/kg, with a standard deviation range of 1.09 to 2.86 mL/kg. Conversion to mg/kg used the specific gravity of 0.956 at 20/4°C.
Hence, Dermal toxicity of N,N-dimethylaniline (LD50) was found to be 1692 mg/kg body weight. This value indicates that N,N-dimethylaniline is classified as category IV for acute toxicity through dermal route.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 692 mg/kg bw
- Quality of whole database:
- The data is of K2 level
Additional information
Acute toxicity: Oral
Based on studies of target substance N,N-dimethylaniline reviewed for acute oral toxicity from reliable sources having Klimisch rating 1, 2 and 4 considering the weight of evidence approach. The summary of the results are presented below
Sr. No |
End point |
Value |
Species |
Remark |
1. |
LD50 |
1348 mg/kg bw |
Rat |
Publication |
2. |
LD50 |
1410 mg/kg bw |
Rat |
Publication |
3. |
LD50 |
951 mg/kg bw |
Rat |
RTECS |
Based on above table, the endpoint value was found to vary between LD50 =951mg/kg bw to1410mg/kg bw .Considering the CLP criteria for classification of substance it is concluded that N,N-dimethylaniline will show toxicity via oral route and classified in acute toxicity 4 category.
Acute toxicity: inhalation
Based on studies of target substance N,N-dimethylaniline reviewed for acute oral toxicity from reliable sources having Klimisch rating 2 and 4 considering the weight of evidence approach. The summary of the results are presented below
Sr. No |
End point |
Value |
Species |
Remark |
1. |
LC50 |
34.299674988 mg/L air |
Mouse |
QSAR Prediction |
2. |
LC50 |
46.786670685 mg/L air |
Rat |
QSAR Prediction |
3. |
LCLo |
250 mg/m³ air |
Rat |
Publication |
4. |
LCLo |
980 mg/m³ air |
Guinea pig |
Publication |
Based on the above values it can be concluded thatN,N-dimethylanilineis not toxic in nature based on the CLP criteria. But since substance has the harmonized classification for acute toxicity, thus can be considered as toxic vial inhalation route to proceed with the harmonized classification.
Acute toxicity: dermal
The acute toxicity by dermal route was examined on the groups of 4 male New Zealand rabbits. All animals were tested using a technique similar to the Draize method. The dose was placed on clipped skin and retained beneath an impervious plastic film for 24 hours.
The lethal dose (LD50) of N,N-dimethylaniline (LD50) was found to be 1692 mg/kg body weight. This value indicates that N,N-dimethylaniline is classified as category 4 for acute toxicity through dermal route.The above value is also supported by publication data in which the LD50 value of N,N-dimethylaniline in rabbit was found to be 1770 mg/kg.
Justification for selection of acute toxicity – oral endpoint
The acute toxicity by oral route was examined on 5 non-fasted, male Carworth-Wistar rats by gastric intubation. In this study, lethal dose (LD50) concentration was found to be 1348 mg/kg.
Justification for selection of acute toxicity – inhalation endpoint
Lowest lethal concentration (LCLo) by inhalation route of N,N-dimethylaniline to rat was found to be 250 mg/m3 indicating that the chemical is moderately toxic.
Justification for selection of acute toxicity – dermal endpoint
The acute toxicity by dermal route was examined on the groups of 4 male New Zealand rabbits. In this study, the dermal toxicity of N,N-dimethylaniline (LD50) was found to be 1692 mg/kg body weight. This value indicates that N,N-dimethylaniline is classified as category IV for acute toxicity through dermal route.
Justification for classification or non-classification
All the values for the route study indicate that the substance N,N-dimethylaniline will qualify for the classification category of Acute tox 4, but since the substance have harmonised classification the same has not been considered for self classification of N,N-dimethylaniline.and would like to go ahead with the harmonized classification.
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