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Diss Factsheets
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EC number: 915-926-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1977
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: no GLP; short report, few details on test substance as well as on results
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Observation ended at 72 hours after start of exposure
- Principles of method if other than guideline:
- Eyes were washed using physiologic salt solution after 24 hours.
Eyes were treated with 0.01 % fluorescine sodium in water before observations at 48 and 72 hours. - GLP compliance:
- no
- Remarks:
- pre-dates GLP
Test material
- Reference substance name:
- N,N-dibutyloleamide and oleic acid, sulphated, sodium salts
- EC Number:
- 915-926-9
- Molecular formula:
- C18H34Na2O6S + C26H52NNaO5S
- IUPAC Name:
- N,N-dibutyloleamide and oleic acid, sulphated, sodium salts
- Test material form:
- liquid
- Details on test material:
- The water content of the actual test item was 57.6% (w/w); the water content of the REACH registration substance was analytically determined to be 3.8% (w/w).
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Himalayan
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 mL per eye
- Duration of treatment / exposure:
- Observations were recorded at 1, 7, 24, 48 and 72 hours after instillation
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- slight turbidity
- Basis:
- animal: 2 out of 3 animals
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: no scores, but a narrative description given in the report
- Irritation parameter:
- conjunctivae score
- Remarks:
- obvious swelling
- Basis:
- animal: all animals
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: no scores, but a narrative description given in the report
- Irritation parameter:
- iris score
- Basis:
- animal: all animals
- Time point:
- 24/48/72 h
- Remarks on result:
- other: No effects reported, no data on individual animals available
- Irritation parameter:
- chemosis score
- Basis:
- animal: all animals
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: no scores, but a narrative description given in the report
- Irritant / corrosive response data:
- Two of three animals showed slight corneal opacity and all animals diffuse reddening of conjunctivae and moderate chemosis. Additionally severely increased secretions were recorded.
The material was evaluated as moderately irritant. - Other effects:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- other: moderately irritating
- Conclusions:
- The test material was moderately irritating to rabbit eyes instillation of 0.1 mL.
- Executive summary:
Three rabbits were treated by instillation of 0.1 mL of the undiluted test material into the conjunctival sac of one eye each. Observations were recorded at 1, 7, 24, 48, and 72 hours after instillation. Eyes were washed using physiologic salt solution after 24 hours.
Eyes were treated with 0.01% fluorescine sodium in water before further observations. The test material elicited slight corneal opacity in 2 of 3 rabbits and diffuse erythema, moderate chemosis and severe discharge in all animals.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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