Registration Dossier
Registration Dossier
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EC number: 213-254-4 | CAS number: 932-64-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study run to a detailed method. None GLP.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Twenty-five young adult (≈ 68 days) Sprague-Dawley male rats were used in the 5 g/kg test group. After the treatment, all animals were observed daily for 30 days for aberrant physiological and behavioral responses.
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- 1,2-dihydro-5-nitro-3H-1,2,4-triazol-3-one
- EC Number:
- 213-254-4
- EC Name:
- 1,2-dihydro-5-nitro-3H-1,2,4-triazol-3-one
- Cas Number:
- 932-64-9
- Molecular formula:
- C2H2N4O3
- IUPAC Name:
- 1,2-dihydro-5-nitro-3H-1,2,4-triazol-3-one
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material : 3-NITRO-1 ,2,4-TRIAZOL-5-0NE (NTO)
- Substance type: energetic explosive
- Physical state: light green to white crystalline solid with no odor
- Purity ca.99%
Constituent 1
- Specific details on test material used for the study:
- Batch No.: not specified
Purity: not specified
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: ≈ 68 days
- Weight at study initiation: 290-330 g
No additonal data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 500 mg/cc of corn oil
- Justification for choice of vehicle: This vehicle was used to solubilize the mixture in an innocuous medium.
No additional data - Doses:
- 5 g/kg
- No. of animals per sex per dose:
- 25 male rats per dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 30 days
- Frequency of observations and weighing: After treatment , all animals were observed daily for 30 days for aberrant physiological and behavioral responses.
No additional data - Statistics:
- None stated
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality
- Clinical signs:
- other: In general, all rat behavioral, clinical, and physiological responses after administration appeared normal.
- Gross pathology:
- No information provided
- Other findings:
- No information provided
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 value for NTO to Sprague-Dawley rat was greater than 5 g/kg.
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