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EC number: 257-856-5 | CAS number: 52334-81-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- 2-chloro-5-(trifluoromethyl)pyridine
- EC Number:
- 257-856-5
- EC Name:
- 2-chloro-5-(trifluoromethyl)pyridine
- Cas Number:
- 52334-81-3
- Molecular formula:
- C6H3ClF3N
- IUPAC Name:
- 2-chloro-5-(trifluoromethyl)pyridine
- Reference substance name:
- 2-chloro-5-(trifluoromethyl) pyridine
- IUPAC Name:
- 2-chloro-5-(trifluoromethyl) pyridine
- Details on test material:
- 2-chloro-5-trifluoromethyl pyridine CTL Number Y02424/003/001, is a white solid with melting point 32°C and boiling point 152°C and a stated purity of >98%w/w. It was supplied by Mond Division, Imperial Chemical Industries PLC, Runcorn Heath, Cheshire UK.
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- C57BL
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Male and femal C57BL/6J mice (6-8 weeks old) were used for both phase I (LD50/7day) and Phase II (Mouse Micronucleus) of the study. The animals were supplied by the Animal Breeding Unit, Alderley Park, Macclesfield, Cheshire.
On arival the mice were housed ten per cage on mobile mouse racks and given food (Porton Combined Diet (PCD) supplied by Special Diets Services Ltd, Stepfield, Witham, Essex, UK) and filtered tap water (via an automated watering system) ad libitum.
The temperature of the animal cell was maintained in the range 20-26°C and a relative humidity range of 36-65%. Temperature and relative humidity were measured on a maximum and minimum thermometer and hygrometer respectively, and were recorded in the CTL Cleanside Temperature Record Book. Lighting was cycled with 12 hours light and dark each 24 hours. The animal cell was under negative pressure with respect to the access corridor and had approximately 22 air changes per hour.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- corn oil
- Details on exposure:
- 2-chloro-5(trifluoromethyl) pyridine was administered as a single intraperitoneal dose to groups of five male and five female mice at the dose levels below. The animals were observed daily for deaths over a seven day period.
- Doses:
- 100, 250, 500, 750, 1000mg/kg/bw
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- The i.p. LD50/7 of CTF was determined in the mouse by calculation from the deaths observed over a seven-day observation period following single intraperitoneal dose.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 750 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 2/5 males dosed at 750mg/kg/bw died within the 7 day observation period
2/5 females dosed at 1000mg/kg/bw died within the 7 day observation period
Any other information on results incl. tables
2-chloro-5(trifluoromethyl) pyridine was administered as a single intraperitoneal dose to groups of five male and five female mice at the dose levels shown. The animals were observed daily for deaths over a seven day period.
Group |
Compound |
Dose mg/kg |
Sex |
Animal Nos. |
No. Deaths |
6 |
CTF |
100 |
M |
26-30 |
0 |
F |
76-80 |
0 |
|||
7 |
CTF |
250 |
M |
31-35 |
0 |
F |
81-85 |
0 |
|||
8 |
CTF |
500 |
M |
36-40 |
0 |
F |
86-90 |
0 |
|||
9 |
CTF |
750 |
M |
41-45 |
2 |
F |
91-95 |
0 |
|||
10 |
CTF |
1000 |
M |
46-50 |
0 |
F |
96-100 |
2 |
Applicant's summary and conclusion
- Conclusions:
- The intraperitoneal LD50 (7 day) for CTF was determined to be 750mg/kg/bw in the mouse.
- Executive summary:
2-chloro-5(trifluoromethyl) pyridine (CTF) was administered in corn oil as a single intraperitoneal dose to groups of five male and five female mice at dose levels of 100, 250, 500, 750 and 1000mg/kg/bw. The animals were observed daily for deaths over a seven day period. The intraperitoneal LD50 (7 day) for CTF was determined to be 750mg/kg/bw in the mouse.
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