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Diss Factsheets
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EC number: 444-960-2 | CAS number: 39148-16-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 Oct - 10 Nov 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- (adopted in 1981)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- 2009
- Deviations:
- yes
- Remarks:
- Geometric standard deviation outside the recommended range (1.5-3.0)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-3 (Acute inhalation toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- THE DEPARTMENT OF HEALTH OF THE GOVERNMENT OF THE UNITED KINGDOM
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Aluminium triethyl triphosphonate
- EC Number:
- 254-320-2
- EC Name:
- Aluminium triethyl triphosphonate
- Cas Number:
- 39148-24-8
- Molecular formula:
- C2H7O3P.1/3Al
- IUPAC Name:
- aluminum tris(ethyl phosphonate)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sprague-Dawley Crl:CD ® BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Ltd, Margate, Kent, UK
- Age at study initiation: approx. 8 - 10 weeks
- Weight at study initiation: 271 - 301 g (males), 222 - 237 g (females)
- Housing: 5 animals of the same sex per cage in stainless steel lids, furnished with soft wood flakes (Dates and Ltd., Cheshire, UK)
- Diet: Rat and Mouse Expanded Diet No.1 (Special Diets Services Limited, Witham, Essex, UK), ad libitum
- Water: ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 2
- Humidity (%): 55 ± 15
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Mass median aerodynamic diameter (MMAD):
- 2.4 µm
- Geometric standard deviation (GSD):
- 0.33
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: cylindric exposure chamber
- Exposure chamber volume: 30 L
- Method of holding animals in test chamber: each rat was individually held in a tapered, polycarbonate restraining tube fitted onto a single tier of the exposure chamber and sealed by means of a rubber O-ring
- Source of air: compressed air (passed through a water trap and respiratory quality filters)
- System of generating particulates/aerosols: Wright's Dust Feed mechanism driven by a variable speed motor
- Method of particle size determination: cascade impactor (six impactor stages with stainless steel collection substrates (10, 6, 3.5, 1.6, 0.9 and 0.5 µm cut-off points) and a back up glass fibre filter housed in an aluminium sampler)
- Treatment of exhaust air: filtered
- Temperature and humidity: 20 ± 1°C and 46 ± 3%
TEST ATMOSPHERE
- Brief description of analytical method used: gravimetrical analysis (chamber concentrations were determined at regular intervals during the exposure period using glass fibre filters (Gelman type A/E 25 mm) placed in filter holders temporarily sealed in a vacant port in the exposure chamber)
- Samples taken from breathing zone: yes
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: please refer to Table 1 under "Any other information on materials and methods incl. tables"
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): 2.4 µm / 0.33 µm
CLASS METHOD (if applicable)
- Rationale for the selection of the starting concentration: based on the expected low toxicity of the test item, a nominal test concentration of 5 mg/L was selected in accordance to the limit concentration defined in OECD Guideline 403. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetric
- Duration of exposure:
- 4 h
- Concentrations:
- 5 mg/L (nominal concentration)
5.11 mg/L (analytical concentration) - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals were observed for clinical signs at hourly intervals during exposure, immediately on removal from the restraining tubes at the end of exposure, one hour after termination of exposure and thereafter once daily. Individual body weights were recorded prior to treatment and on Days 7 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology, other: behavioural observations - Statistics:
- Mean values and standard errors were calculated from the examined parameters.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.11 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No mortality occured during the exposure and observation period.
- Clinical signs:
- other: During the exposure period, animals showed signs of wet fur (10/10), laboured respiration (5/5 males, 1/5 females) and a decreased respiration rate (3/5 males and females). Immediately after removal of the chamber, all animals revealed wet fur, hunched po
- Body weight:
- A possible reduction in body weight gain was observed in male animals during the first week of the 14 day observation period: body weight increased around 16 - 23 or 3 - 19 g during week 1 in male and female animals, respectively. Afterwards, increases around 26 - 57 or 4 - 18 g were determined during week 2 in males and females, respectively.
- Gross pathology:
- No abnormalities were observed in exposed animals except dark red foci on the lungs of 3/5 males and 1/5 females.
Any other information on results incl. tables
Table 2. Acute inhalation toxicity of Fosetyl Al.
Target concentration |
Toxicological results* |
Duration of clinical signs |
Time of death |
Mortality (%) |
Males |
||||
5.11 |
0/5/5 |
Day 0 - 4 (longest) |
--- |
0 |
Females |
||||
5.11 |
0/5/5 |
Day 0 - 2 |
--- |
0 |
LC50 > 5.11 mg/L air |
* first number = number of dead animals
second number = number of animals with clinical signs
third number = number of animals used
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008
- Conclusions:
- Under the conditions chosen, no mortality was observed. Thus, the LC50 was determined to be greater than 5.11 mg/L air.
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