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EC number: 463-070-5 | CAS number: 106966-25-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22.10. to 9.11.2007.
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 463-070-5
- EC Name:
- -
- Cas Number:
- 106966-25-0
- Molecular formula:
- C7H17N2O2Br
- IUPAC Name:
- 2-(3-methoxy-3-oxopropyl)-1,1,1-trimethylhydrazinium bromide
Constituent 1
Test solutions
- Details on test solutions:
- Test solution: dilution water
Standard dilution water was prepared just before the test by admixing 2.5 mL ofstored solutions A, B, C and D in 1000 mL of distilled water.
A. 117.6 g CaCl2 . 2 H2O in 1 L distilled water
B. 49.3 g MgSO4 . 7 H2O in 1 L distilled water
C. 25.9 g NaHCO3 in 1 L distilled water
D. 2.3 g KCl in 1 L distilled water
The dilution water should be of pH 7.8 ± 0.2. It is satured by oxygen by the aeration attemperature of 20-24 degree of Celsius. The content of sum Ca + Mg ions should have the value of 2.5 mmol/L.
Test organisms
- Test organisms (species):
- Poecilia reticulata
- Details on test organisms:
- TEST ORGANISM
- Common name: Poecilia reticulata
- Source: certificied supplier BioTest s.r.o., Konarovice (Czech Republic);
- Age at study initiation: 3-4 months old;
- Length at study initiation: 2.0-3.0 cm;
- Weight at study initiation (mean and range, SD): 0.3 g (range 0.2-0.6 g);
- Feeding during test
- Food type: "Tropica" - feed for aquarium fish. Fish were not fed during 72 hours before the test
ACCLIMATION
- Acclimation period: 7 days in dilution water;
- Acclimation conditions: the fish were kept in all-glass aquaria in aerated drinking water;
- Health during acclimation: the sensitivity of test species is periodically monitored by testing with the reference substance - potassium dichromate.
Study design
- Test type:
- static
- Limit test:
- yes
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- Content of (Ca + Mg) ions: 2.59 mmol/L
- Test temperature:
- 21.1 degree Celsius(C)
- pH:
- pH of dilution water: 8.0
- Dissolved oxygen:
- 8.4 mg/L
- Nominal and measured concentrations:
- 100, 91, 83, 75, 68 and 62 mg in 1000 mL of dilution water
- Details on test conditions:
- Temperature: 22 ± 2 degree of Celsium, with a variation of ± 1 degree of Celsium at each individual test
Exposure time: 96 hours
Lighting: daylight
Loading: maximum loading of 1 g per litre
Number of animals at one concentration level: 7 fish for the preliminary test, 10 fish for the limit test
Concentration of dissolved oxygen: it must be at least 60 % of the air saturation value at given temperature through the test.
Design of test: static test
Without feeding, without aeration. - Reference substance (positive control):
- yes
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Duration:
- 48 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Duration:
- 72 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
Applicant's summary and conclusion
- Conclusions:
- Test substance is not assigned to any of quoted toxicity categories.
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