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Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 25, 2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The study has been conducted according to internationally recognised guideline, under GLP. No deviation from guideline are reported. The substance is adequately identified. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- 2009
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- GLP-BESCHEININGUNG Statement of GLP Compliance (inspected on 28-29 April 2021, signed on 21 June 2021)
- Type of method:
- static method
- Temp.:
- 25 °C
- Vapour pressure:
- 4 241 Pa
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 3 346 Pa
- Conclusions:
- The vapour pressure of the test item was determined to be 3346 Pa at 20.0 °C and 4241 Pa at 25.0 °C.
- Executive summary:
An experimental study, conducted in accordance to OECD 104 / EU A.4 and under GLP, was conducted. The vapour pressure was measured using the static method. Five pairs of temperature and pressure were measured and the experiment was repeated in reversed order for confirmation. The points were used to calculate a regression curve from which vapour pressure at ambient temperature was determined.
The vapour pressure of the test item was determined to be 3346 Pa at 20.0 °C and 4241 Pa at 25.0 °C.
The values of the heating and cooling down phase showed good correspondence.
Therefore, the result of the study is considered valid.
Reference
Findings
Measurement Values
The measured values are presented in the following table.
Table 2 - Measurement Values, Date: 25. Oct. 2022
1. Determination | 2. Determination | ||||
Temp. in °C | Time | Pressure in hPa | Temp. in °C | Time | Pressure in hPa |
20.0 | 10:10 | 32.0 | 48.5 | 13:50 | 116.9 |
29.7 | 11:20 | 53.7 | 40.1 | 14:15 | 84.5 |
39.4 | 11:55 | 83.0 | 33.4 | 14:35 | 62.1 |
49.2 | 13:00 | 120.3 | 24.9 | 14:55 | 42.1 |
57.1 | 13:30 | 158.3 | 15.6 | 15:15 | 27.2 |
Results
The calculation results are presented in the following table:
Table 3 - Calculated values for 1/T and log P
n | Temperature T | Pressure p | Temperature T | 1/T | log p |
| °C | hPa | K | 1/K | log Pa |
1 | 20.0 | 32.0 | 293.15 | 0.00341122 | 3.5051 |
2 | 29.7 | 53.7 | 302.85 | 0.00330196 | 3.7300 |
3 | 39.4 | 83.0 | 312.55 | 0.00319949 | 3.9191 |
4 | 49.2 | 120.3 | 322.35 | 0.00310222 | 4.0803 |
5 | 57.1 | 158.3 | 330.25 | 0.00302801 | 4.1995 |
6 | 48.5 | 116.9 | 321.65 | 0.00310897 | 4.0678 |
7 | 40.1 | 84.5 | 313.25 | 0.00319234 | 3.9269 |
8 | 33.4 | 62.1 | 306.55 | 0.00326211 | 3.7931 |
9 | 24.9 | 42.1 | 298.05 | 0.00335514 | 3.6243 |
10 | 15.6 | 27.2 | 288.75 | 0.00346320 | 3.4346 |
The parameters for the linear regression of the graph log (p) vs. 1/T are presented in the following table:
Table 4 - Linear Regression Parameters
Parameter | Value |
Slope | -1798.503772 |
Intercept | 9.659644756 |
Correlation coefficient r | -0.999203919 |
Coefficient of determination r2 | 0.998408471 |
Using the equation of the regression log p vs. 1/T and reorganizing it, vapour pressures at ambient temperature were calculated as:
Table 5 - Calculated Values for vapour pressure
Parameter | Value | Unit |
Vapour Pressure (20.0 °C) | 3346 | Pa |
Vapour Pressure (25.0 °C) | 4241 | Pa |
The vapour pressure of the test item was determined to be 3346 Pa at 20.0 °C and 4241 Pa at 25.0 °C.
The coefficient of determination r2 was calculated with 0.998408471. This value is above the threshold of 0.95.
The values of the heating and cooling down phase showed good correspondence.
Therefore, the result of the study is considered valid.
Description of key information
The vapour pressure of the test item was determined to be 3346 Pa at 20.0 °C and 4241 Pa at 25.0 °C.
Key value for chemical safety assessment
- Vapour pressure:
- 3 346 Pa
- at the temperature of:
- 20 °C
Additional information
An experimental study, conducted in accordance with conditions recommended in OECD guideline and under GLP, is performed. It should be considered as a key study. The result should be retained as key data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
