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EC number: 814-217-0 | CAS number: 353258-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OCSPP 850.4500 (Algal Toxicity) (January 2012)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
- Cas Number:
- 353258-35-2
- Molecular formula:
- C9H4ClF3N2O2
- IUPAC Name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
1
- Specific details on test material used for the study:
- Test substance: IN-QEK31-011
Batch No.: SG0312574
Purity: 98.2%
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
- Remarks:
- OECD test media
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
Study design
- Test type:
- static
- Water media type:
- other: OECD test media
- Total exposure duration:
- 96 h
Test conditions
- Test temperature:
- 23.3 - 24.4°C
- pH:
- 6.8 to 8.1 at test initiation and 9.0 to 9.3 at test termination
- Nominal and measured concentrations:
- Nominal Concentration: 0, 7.5, 15, 30, 60, 120, and 120 (abiotic control) mg a.s./L
Measured Concentration (72 h): 0, 7.51, 15.1, 30.0, 60.2, and 116, and 116 (abiotic control) mg a.s./L
Measured Concentration (96 h): 0, 7.37, 14.9, 29.9, 59.4, and 116, and 116 (abiotic control) mg a.s./L
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 116 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: area under the growth curve, yield, and growth rate from time zero
- Remarks:
- Area Under Growth Curve
- Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 116 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: area under the growth curve, yield, and growth rate from time zero
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 116 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: area under the growth curve, and growth rate from time zero
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 7.51 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- yield
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 116 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: area under the growth curve, yield, and growth rate from time zero
- Duration:
- 72 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 116 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: area under the growth curve, and growth rate from time zero
- Duration:
- 72 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 15.1 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- yield
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 116 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: area under the growth curve, yield, and growth rate from time zero
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- 72-hour EC50: > 116 mg a.s./L (area under the growth curve, yield, and growth rate from time zero)
96-hour EC50: > 116 mg a.s./L (area under the growth curve, yield, and growth rate from time zero)
72-hour NOEC: 116 mg a.s./L (area under the growth curve, and growth rate from time zero)
72-hour NOEC: 7.51 mg a.s./L (yield)
96-hour NOEC: 116 mg a.s./L (area under the growth curve, yield, and growth rate from time zero)
72-hour NOEC: >116 mg a.s./L (area under the growth curve, and growth rate from time zero)
72-hour NOEC: 15.1 mg a.s./L (yield)
96-hour NOEC: >116 mg a.s./L (area under the growth curve, yield, and growth rate from time zero) - Executive summary:
The acute toxicity of the test item to the unicellular green alga, Pseudokirchneriella subcapitata, was determined in a 96-hour growth inhibition test. The test was conducted in accordance with the U.S. Environmental Protection Agency, Ecological Effects Test Guidelines, OCSPP 850.4500 and OECD Guideline No. 201. Treatments consisted of an untreated control, an abiotic (stability) control, and five nominal concentrations of 7.5, 15, 30, 60, and 120 mg a.s./L. The corresponding 72-hour mean measured concentrations of the test item were 7.51, 15.1, 30.0, 60.2, and 116 mg a.s./L. The corresponding 96-hour mean measured concentrations of the test item were 7.37, 14.9, 29.9, 59.4, and 116 mg a.s./L. The 96-hour measured concentration of the test item in the nominal 120 mg a.s./L abiotic control was 116 mg a.s./L. The 72- and 96-hour EC50 and NOEC for Pseudokirchneriella subcapitata were based on 72- and 96-hour mean, measured concentrations, respectively, of the test item and area under the growth curve, growth rate, and yield. The 72-hour EbC50, ErC50, and EyC50 values based on area, growth rate, and yield were >116 mg a.s./L. The 72-hour NOEC value based on area, growth rate, and yield was 116, 116, and 7.51 mg a.s./L (72-hour mean, measured concentrations), respectively. The 96-hour EbC50, ErC50, and EyC50 values based on area, growth rate, and yield were >116 mg a.s./L. The 96-hour NOEC value based on area, growth rate, and yield were 116 mg a.s./L (96-hour mean measured concentrations), respectively.
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