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Diss Factsheets
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EC number: 701-340-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- OECD guideline 203. GLP study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Principles of method if other than guideline:
- The Notice on the Test Method Concerning New Chemical Substances < Algal Growth Inhibition Test, Daphnia Acute Immobilization Test, and Fish Acute Toxicity Test >
- GLP compliance:
- yes
- Specific details on test material used for the study:
- STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Solubility and stability of the test substance in the test medium: Since the test substance is a poorly water-soluble inorganic compound, the test was carried out using the test item in the dispersed state. The ratio of the measured value to the nominal value was 91 to 92% at the time of preparation of the test solution and 89 to 90% after 24 hours (renewal). As a reference, the filtrate obtained by filtering the test solution (0.45μm) was similarly analyzed to confirm the concentration of the test substance dissolved in the test solution; the average value of the test substance concentration in the filtrate was less than the detection limit (<0.296 mg/L). - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 0 (control), 100 mg/L
- Sampling method: the concentration of test item was verified at 0 and 24 hours. - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Since the test substance is a poorly water-soluble inorganic compound, the test was carried out using the test item in the dispersed state. - Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- TEST ORGANISM
- Common name: Japanese rice fish (medaka)
- Strain: Latipes - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Test temperature:
- 24 ± 1ºC
- Nominal and measured concentrations:
- - 0 (control), 100 mg/L (nominal); 90.2 mg/L (measured).
- The ratio of the measured value to the nominal value was 91 to 92% at the time of preparation of the test solution and 89 to 90% after 24 hours. - Details on test conditions:
- TEST SYSTEM
- Material, size, headspace, fill volume: 5.0 L/vessel
- Renewal rate of test solution (frequency/flow rate): 24h
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours light / 8 hours dark
- Light intensity: room light (less than 1000 lux)
EFFECT PARAMETERS MEASURED: mortality - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 90.2 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- > 90.2 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 90.2 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Mortality of control: none reported
- Dissolved oxygen concentration: not specified - Validity criteria fulfilled:
- yes
- Conclusions:
- The 96h-LC50 of the test item in rice fish was determined to be > 90.2 mg/L, based on measured concentration.
- Executive summary:
An acute fish toxicity test was conducted according to OECD 203, under GLP conditions. To establish the toxicity of the test material to the rice fish (Oryzias latipes), a limit test was performed under semi-static conditions (renewal rate 24h). 10 fish per concentration were exposed to 100 mg/L test item (nominal concentration) or the control for 96 h at 24 ± 1 ºC. No mortality was observed. The concentration of test item was verified at 0 and 24 hours by ICP-MS. Under test conditions, the 96h-LC50 of the test item in rice fish was determined to be > 90.2 mg/L, based on measured concentration.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- June 1976
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- The study is not well documented. No GLP study.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No data on test guideline
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Number of test organisms per vessel: 10
Average weight: 1.5g
Average length: 49.8 mm - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 36 (CaCO3)
- Test temperature:
- 15ºC. Range during test 14.5 to 15.5ºC
- pH:
- Initial pH: 7.85. Range during test: 7.4 to 7.8
- Dissolved oxygen:
- 91% saturation, range during test 84 to 98% saturation
- Details on test conditions:
- Test vessel material: glass
Test vessel capacity: 5 litres
Dimensions of the vessel: 160mm(W)x300 mm(H) - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- other: TLm=TL50
- Effect conc.:
- > 32 000 mg/L
- Conc. based on:
- test mat.
- Remarks on result:
- other: TLm=TL50 Median Lethal Time
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The result was as follows:
96hr TLm (Median Lethal Time, or TL50) >32000 mg/l - Executive summary:
The test was conducted to establish the toxicity of the test material to the Rainbow Trout fishes.
There is no information about the used guideline.
There is no information about the tested concentration.
The result was as follows:
96hr TLm (Median Lethal Time, or TL50) >32000 mg/l
Referenceopen allclose all
Description of key information
Key study. Method according to OECD 203, GLP study. The 96h-LC50 of the test item in rice fish (Oryzias latipes) was determined to be > 90.2 mg/L (measured concentration).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 90 mg/L
Additional information
Supporting study. Data from a supporting study reports a 96-hr TLm > 32000 mg/L in Rainbow Trout (Oncorhynchus mykiss). No further information is available.
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