Registration Dossier
Registration Dossier
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EC number: 695-022-6 | CAS number: 473278-76-1
Toxicity to birds
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The endpoint “toxicity to birds” is not a data requirement for the registered substance. However, for the sake of completeness this endpoint is covered by a short summary of the available data.
The acute oral and short-term dietary toxicity of tefuryltrione was assessed in the Bobwhite quail (Colinus virginianus, OECD 223 & 205, GLP), the Japanese quail (Coturnix coturnix japonica, OECD 223, GLP), and Mallard duck (Anas platyrhynchos, OECD 205, GLP).
Tefuryltrione was of low acute oral and short-term dietary toxicity to Bobwhite quail, Japanese quail and Mallard duck since the acute oral LD50 was >2000 mg/kg body weight in all studies. Moreover, the dietary LC50 was >3980 mg/kg feed for Bobwhite quail and >4213 mg/kg feed for Mallard duck, indicating low short-term toxicity.
Beside one premature death, mortalities were observed at 2000 mg a.i./kg bw in the acute oral test with Japanese quail. Therefore, the non-lethal dose (NLD) was at 1734 mg a.i./kg bw. No mortalities occurred in the study with Bobwhite quail.
Dietary treatment up to 3980 mg/kg feed to Bobwhite quail had no effect on survival, growth and food consumption of the birds. The only effect observed in Mallard duck was a temporary change in food consumption of dosed birds compared to the control group.
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