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EC number: 700-169-7 | CAS number: 7646-67-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 July 2007 to 6 September 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products: 5 min, 2.4 hours and 120 hours.
- Sampling method: At each sampling time, duplicate samples were removed from the waterbath and an aliquot (1 ml) was diluted to volume (100 ml) with acetone for analysis by gas chromatography (GC). Additional data were obtained at pH 9 with filtration (0.2 μm, PTFE) prior to analysis, as it was apparent that precipitation of buffer salts from solution at this pH value caused some deterioration in the chromatography. - Buffers:
- - pH: 4.0
- Type and final molarity of buffer:
- Composition of buffer:Potassium dihydrogen orthophosphate (3.00 g) and disodium hydrogen orthophosphate dodecahydrate (6.42 g) were dissolved in purified water (950 ml) and the pH was adjusted to 4.0 ± 0.05 with orthophosphoric acid. The volume was
then adjusted to 1000 ml with purified water.
- pH: 7.0
- Type and final molarity of buffer:
- Composition of buffer:Potassium dihydrogen orthophosphate (6.82 g) was dissolved in purified water (950 ml) and 1M sodium hydroxide (30 ml) was added to produce a solution of pH 7.0 ± 0.05. The volume was then adjusted to 1000 ml with purified water.
- pH: 9.0
- Type and final molarity of buffer:
- Composition of buffer:Disodium tetraborate decahydrate (16.6 g) and potassium dihydrogen orthophosphate (1.80 g) were dissolved in purified water (950 ml) to produce a solution of pH 9.0 ± 0.05. The volume was then adjusted to 1000 ml with purified water. - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: 10 mL Wheaton vials
- Measures taken to avoid photolytic effects: samples were placed in a 50oC water batch in the dark until sampling was required. - Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.88 g/L
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.96 g/L
- Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 1.03 g/L
- Number of replicates:
- 2 replicates at each pH
- Preliminary study:
- Results from the preliminary investigation showed that there was no significant change in the concentration of HEAA when incubated in pH 4, 7 and 9 buffer solutions at 50 ± 0.5ºC. Less than 10% hydrolysis had occurred after 120 hours (5 days) under these conditions, equivalent to a half-life of greater than 1 year under environmental conditions (25°C).
Two sets of results are presented for the pH 9 test, from the analyses of both filtered and unfiltered samples. Although there was some variability in the results, it was evident that no significant hydrolysis had occurred when all the data were considered as a single set. - Transformation products:
- not measured
- % Recovery:
- > 90
- pH:
- 4
- Temp.:
- 50
- Duration:
- 120 h
- % Recovery:
- > 90
- pH:
- 7
- Temp.:
- 50
- Duration:
- 120 h
- % Recovery:
- > 90
- pH:
- 9
- Temp.:
- 50
- Duration:
- 120 h
- pH:
- 4
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 7
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 9
- Remarks on result:
- hydrolytically stable based on preliminary test
- Validity criteria fulfilled:
- yes
- Conclusions:
- HEAA was determined to be hydrolytically stable under acidic, neutral and basic conditions.
- Executive summary:
The hydrolysis test was performed in accordance with the preliminaty test as described in EU Method C7 and OECD Guideline 111.
Results from the preliminary investigation showed that there was no significant change in the concentration of HEAA when incubated in pH 4, 7 and 9 buffer solutions at 50 ± 0.5ºC. HEAA was determined to be hydrolytically stable under acidic, neutral and basic conditions.
Reference
Description of key information
The preliminary study showed that at pH 4, 7 and 9 and 50 ± 0.5ºC, less than 10% hydrolysis had occurred after 120 hours (5 days), equivalent to a half-life of greater than 1 year under environmental conditions (25°C).
HEAA was determined to be hydrolytically stable under acidic, neutral and basic conditions.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
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