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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The 2-methylcyclohexanone was screened for acute toxicity: oral, dermal and through inhalation (Smyth et al., 1969):
• oral: 2-methylcyclohexanone LD50: =1370 - 2868 mg/kg bw


• dermal: 2-methylcyclohexanone LD50: 1637 mg/kg bw


• inhalation: 2-methylcyclohexanone LD50: 2800 ppm.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
No description of the guideline available
GLP compliance:
not specified
Species:
rat
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 1 370 - <= 2 868 mg/kg bw
Based on:
test mat.
Remarks on result:
other: calculated value considering LD50 value reported in mL/Kg, converted to mg/Kg by considering density
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 1.48 - <= 3.1 mL/kg bw
Based on:
test mat.
Remarks on result:
other: value as reported in the study
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The 2-methylcyclohexanone and the source cyclohexanone show similar single oral toxicity in rats, with a slight lesser toxic dose for the target compound 2-methylcyclohexanone (Smyth et al., 1969):
• 2-methylcyclohexanone LD50: 2.14 (1.48-3.10) ml/kg
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
1 370 - 2 868 mg/kg bw

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Principles of method if other than guideline:
No description of the guideline available
GLP compliance:
not specified
Species:
rat
Sex:
not specified
Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Key result
Sex:
not specified
Dose descriptor:
LC50
Effect level:
2 800 ppm
Based on:
test mat.
Exp. duration:
4 h
Mortality:
50%
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
2-methycyclohexanone has an acute inhalative LC50 of 2800 ppm. As a result, the substance meets the criteria for classification for Category 4 according to Regulation (EC) No 1272/2008, Annex I section 3.1.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LC50
Value:
2 800 ppm air

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
No description of the guideline available
GLP compliance:
not specified
Species:
rabbit
Strain:
not specified
Sex:
not specified
Type of coverage:
not specified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
<= 1 637 mg/kg bw
Based on:
test mat.
Remarks on result:
other: calculated value considering LD50 value reported in mL/Kg, converted to mg/Kg by considering density
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1.77 mL/kg bw
Based on:
test mat.
Remarks on result:
other: value as reported in the study
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
2-methycyclohexanone has an acute dermal LD50 of 1.77 mL/Kg. As a result, the substance meets the criteria for classification for Category 1 according to Regulation (EC) No 1272/2008, Annex I section 3.1.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
1 637 mg/kg bw

Additional information

Justification for classification or non-classification

Acute Toxicity, oral: 2-methycyclohexanone has an acute oral LD50 of ≤ 2 000 (acute oral LD50 = 1370 mg/kg bw - 2868 mg/kg bw). As a result, the substance meets the criteria for classification for Category 4 according to Regulation (EC) No 1272/2008, Annex I section 3.1.


Acute Toxicity, dermal: 2-methycyclohexanone has an acute dermal LD50 ≤ 2 000 (acute dermal LD50 =1637 mg/Kg bw). As a result, the substance meets the criteria for classification for Category 4 according to Regulation (EC) No 1272/2008, Annex I section 3.1.
Acute Toxicity, inhalative: 2-methycyclohexanone has an acute inhalative LC50 of 2800 ppm. As a result, the substance meets the criteria for classification for Category 4 according to Regulation (EC) No 1272/2008, Annex I section 3.1.