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EC number: 410-400-0 | CAS number: 88671-89-0 SYSTHANE TECHNICAL
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-07-18 to 2017-09-26
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 106 (Adsorption - Desorption Using a Batch Equilibrium Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- batch equilibrium method
- Media:
- soil
- Radiolabelling:
- yes
- Test temperature:
- 20 ± 2°C.
- Analytical monitoring:
- yes
- Details on sampling:
- Nominal test item concentrations of 1.25, 0.625, 0.125, 0.0625 and 0.0125 µg/mL. Duplicate samples were prepared for each soil for analysis at each concentration.
- Matrix no.:
- #1
- Matrix type:
- silty clay
- % Clay:
- 42
- % Silt:
- 42
- % Sand:
- 16
- % Org. carbon:
- 1.6
- CEC:
- 16.5 meq/100 g soil d.w.
- Matrix no.:
- #2
- Matrix type:
- loam
- % Clay:
- 26
- % Silt:
- 45
- % Sand:
- 29
- % Org. carbon:
- 5
- CEC:
- 18.5 meq/100 g soil d.w.
- Matrix no.:
- #3
- Matrix type:
- clay loam
- % Clay:
- 39
- % Silt:
- 21
- % Sand:
- 40
- % Org. carbon:
- 7.6
- CEC:
- 33.1 meq/100 g soil d.w.
- Matrix no.:
- #4
- Matrix type:
- loamy sand
- % Clay:
- 7
- % Silt:
- 8
- % Sand:
- 85
- % Org. carbon:
- 1.46
- CEC:
- 5.7 meq/100 g soil d.w.
- Matrix no.:
- #5
- Matrix type:
- silt loam
- % Clay:
- 19
- % Silt:
- 50
- % Sand:
- 31
- % Org. carbon:
- 2.85
- CEC:
- 14.8 meq/100 g soil d.w.
- Details on matrix:
- Soil 1: Fr1, (St Bauzille de la Silve, Herault, France).
Soil 2: E1, (Brierlow, Derbyshire, UK)
Soil 3: J1, (Chapel Hill Farm, Rutland, UK)
Soil 4: A1, (Warsop, Nottinghamshire, UK)
Soil 5: E3, (Kenslow Farm, Derbyshire, UK)
Soil 1 PH in water, in 0.01 M CaCl2: 8.2, 7.7.
Soil 2 PH in water, in 0.01 M CaCl2: 5.9, 5.3.
Soil 3 PH in water, in 0.01 M CaCl2: 8.0, 7.4.
Soil 4 PH in water, in 0.01 M CaCl2: 4.2, 3.7.
Soil 5 PH in water, in 0.01 M CaCl2: 5.7, 5.5.
USDA 1995 textural classification system. Air dried soil, passed through 2 mm sieve prior to use. - Details on test conditions:
- SETUP:
The sample tubes used in this study were 50 mL polypropylene conical-based centrifuge tubes. An appropriate amount of the air dried soil was weighed into clean, conical tubes. End-over-end shakers were rotating cylinders to which the centrifuge tubes were attached for the required periods. Equilibration of test item in soil and 0.01 M CaCl2 was carried out in the dark in a temperature controlled room maintained at 20 ± 2°C. Centrifugation and measurement of the supernatants was carried out at ambient temperature under normal laboratory lighting conditions.
Weights of soil (ca 1.75 g for E1, J1, A1 and A3, soils and ca 8.75 g for Fr1 soil, at the optimal soil solution ratio) when referred to in the text as being weighed into the centrifuge tubes, are for air dried soil. For calculation of the adsorption/desorption parameters the moisture content of air dried soils has been corrected for in the calculations and results are expressed on an oven dry basis.
Equilibration solution: 0.01M CaCl2 (31.5 mL).
Control conditions (blank): Soil and 0.01M CaCl2 (no test item); 0.01M CaCl2 and test item (no soil).
Replicates: Blank:1, treated: 2.
Soil to Solution ratio: 1:20 for E1, J1, A1 and A3; 1:4 for Fr1
Centrifugation: 3000 G, 15 minutes, decanting supernatant. - Sample No.:
- #1
- Duration:
- 48 h
- Temp.:
- 20 °C
- Remarks:
- End-ove- end shaker
- Sample No.:
- #2
- Duration:
- 48 h
- Temp.:
- 20 °C
- Remarks:
- End-over-end shaker
- Sample No.:
- #3
- Duration:
- 48 h
- Temp.:
- 20 °C
- Remarks:
- End-over-end shaker
- Sample No.:
- #4
- Duration:
- 48 h
- Temp.:
- 20 °C
- Remarks:
- End-over-end shaker
- Sample No.:
- #5
- Duration:
- 48 h
- Temp.:
- 20 °C
- Remarks:
- End-over-end shaker
- Sample no.:
- #1
- Duration:
- 24 h
- Temp.:
- 20 °C
- Remarks:
- End-over-end shaker
- Sample no.:
- #2
- Duration:
- 24 h
- Temp.:
- 20 °C
- Remarks:
- End-over-end shaker
- Sample no.:
- #3
- Duration:
- 24 h
- Temp.:
- 20 °C
- Remarks:
- End-over-end shaker
- Sample no.:
- #4
- Duration:
- 24 h
- Temp.:
- 20 °C
- Remarks:
- End-over-end shaker
- Sample no.:
- #5
- Duration:
- 24 h
- Temp.:
- 20 °C
- Remarks:
- End-over-end shaker
- Key result
- Sample No.:
- #1
- Type:
- Koc
- Value:
- > 410 - < 637 L/kg
- pH:
- 7.7
- Temp.:
- 20 °C
- % Org. carbon:
- 1.6
- Remarks on result:
- other: Silty Clay
- Key result
- Sample No.:
- #2
- Type:
- Koc
- Value:
- > 630 - < 886 L/kg
- pH:
- 5.3
- Temp.:
- 20 °C
- % Org. carbon:
- 5
- Remarks on result:
- other: Loam
- Key result
- Sample No.:
- #3
- Type:
- Koc
- Value:
- > 275 - < 588 L/kg
- pH:
- 7.4
- Temp.:
- 20 °C
- % Org. carbon:
- 7.6
- Remarks on result:
- other: Clay Loam
- Key result
- Sample No.:
- #4
- Type:
- Koc
- Value:
- > 1 070 - < 1 506 L/kg
- pH:
- 3.7
- Temp.:
- 20 °C
- % Org. carbon:
- 1.5
- Remarks on result:
- other: Loamy Sand
- Key result
- Sample No.:
- #5
- Type:
- Koc
- Value:
- > 720 - < 1 020 L/kg
- pH:
- 5.5
- Temp.:
- 20 °C
- % Org. carbon:
- 2.9
- Remarks on result:
- other: Silt Loam
- Key result
- Sample No.:
- #1
- Type:
- Kd
- Value:
- > 6.56 - < 10.2 L/kg
- pH:
- 7.7
- Temp.:
- 20 °C
- % Org. carbon:
- 1.6
- Remarks on result:
- other: Silty Clay
- Key result
- Sample No.:
- #2
- Type:
- Kd
- Value:
- > 31.49 - < 44.29 L/kg
- pH:
- 5.3
- Temp.:
- 20 °C
- % Org. carbon:
- 5
- Remarks on result:
- other: Loam
- Key result
- Sample No.:
- #3
- Type:
- Kd
- Value:
- > 20.9 - < 44.66 L/kg
- pH:
- 7.4
- Temp.:
- 20 °C
- % Org. carbon:
- 7.6
- Remarks on result:
- other: Clay Loam
- Key result
- Sample No.:
- #4
- Type:
- Kd
- Value:
- > 15.62 - < 21.99 L/kg
- pH:
- 3.7
- Temp.:
- 20 °C
- % Org. carbon:
- 1.5
- Remarks on result:
- other: Loamy Sand
- Key result
- Sample No.:
- #5
- Type:
- Kd
- Value:
- > 20.52 - < 30.5 L/kg
- pH:
- 5.5
- Temp.:
- 20 °C
- % Org. carbon:
- 2.9
- Remarks on result:
- other: Silt Loam
- Adsorption and desorption constants:
- Please see Table 1 and Table 2 below.
- Recovery of test material:
- The material balance at each concentration of each test soil was determined. The material
balance at the highest concentration was determined as the sum of the amount of test substance
in the adsorption and desorption phases, soil extracts and extracted soil residues. This procedure
was also carried out for all loamy sand (A1) samples as the initial mass balance results were
below 90% AR. For the remaining samples the mass balance was determined from the sum of
the amount of test substance in the adsorption and desorption phases and soil residues. The
material balances ranged from mean values of 92.9% to 100.5% AR for all soils, which were
within the acceptable guideline range of 90-110% of the applied radioactivity. - Transformation products:
- not specified
- Details on results (Batch equilibrium method):
- SOLUBILITY AND ADDSORPTION TO TEST VESSELS:
The solubility of the test item was measured to determine if the test item was soluble at a concentration of at least 20 µg/mL. Therefore, the highest test solution concentration of 1.25 µg/mL was safely below the aqueous solubility limit.
Adsorption tests showed no adsorption to either polypropylene centrifuge tubes or amber glass
jars.
ADSORPTION:
The values for the adsorption coefficients, Kd and Koc were calculated for all five soils at each of the five test solution concentrations. The values for the Freundlich adsorption isotherm parameters, KF, KFoc and 1/n were derived from the linear form of the Freundlich equation for all five test systems. The values of Koc from the adsorption isotherms indicate that [14C]-myclobutanil has a medium to low mobility in soil. The results of the values of 1/n for each of the systems (ca > 0.9, except J1 Clay Loam) indicates that adsorption is linear over the range of concentrations tested. The random variation in Kd values with respect to soil organic carbon and pH indicates that there is no correlation between adsorption and the organic carbon content or pH of the test system.
DESORPTION:
The values for the desorption coefficients, Kdes and Koc,des were calculated for all five soils at each of the five test solution concentrations. The values for the Freundlich desorption isotherm parameters, KF,des, KFoc,des and 1/n were derived from the linear form of the Freundlich equation for all five test systems. The results from the desorption isotherms indicate that desorption is linear over the range of concentrations tested., with the value of 1/n for each of the systems ca > 0.9 (except J1, Clay Loam). The range of Koc,des / KFoc,des values indicates that there is not a strong correlation between desorption and the organic carbon content of the test system. - Conclusions:
- The arithmetic mean of the Koc-value of myclobutanil was calculated to be 774 at 20°C.
Based on the results of the study [14C]-myclobutanil was shown to have medium to low mobility in the soils tested. The 1/n values for both adsorption and desorption indicated that both adsorption and desorption were linear over the range of concentrations tested. No correlation was observed between the pH or organic carbon content of the test system and the Kd values. - Executive summary:
The study was designed to investigate the adsorption and desorption properties of [14C]-myclobutanil in 5 soil types. The experiment was conducted in accordance with the OECD Guidelines for testing of chemicals, OECD Guideline 106: Adsorption-Desorption Using a Batch Equilibrium Test (January 2000).
The adsorption and desorption properties of [14C]-myclobutanil were investigated in the current study to assess its potential mobility in soils. The adsorption coefficients (Kd and Koc), the desorption coefficients (Kdes and Koc,des), the Freundlich adsorption isotherm parameters (KF, KFoc and 1/n) and the Freundlich desorption isotherm parameters (KF,des, KFoc,des, and 1/n) were calculated.
The texture (USDA) of the soils included silty clay (Fr1), loam (E1), clay loam (J1), loamy sand (A1) and silt loam (E3). The percent organic matter of the soils ranged from 2.7% to 13.1% (1.6% to 7.6% organic carbon). The pH ranged from 3.7 to 7.7 as measured in 1:1 soil:0.01 M CaCl2.Adsorption and desorption isotherm experiments were performed using the batch equilibration method on all soils with five nominal concentrations (1.25, 0.625, 0.125, 0.0625 and 0.0125 μg/mL) of the test substance in aqueous 0.01 M CaCl2. A desorption cycle was performed on all samples at all concentrations. A 1:20 (w/w) soil-to-solution ratio was used for all soils except Fr1 (S1013) which was tested at a 1:4 (w/w) ratio.
The sorption coefficients Kd and KOC were calculated for each soil at each concentration of the test substance. The values for the Freundlich adsorption isotherm parameters KF, KFoc, and 1/n were derived from the linear form of the Freundlich equation and summarised below.
Soil Type
OC
%
Soil pH
Kd (mL/g)
Kdoc (mL/g)
KF
(mL/g)
KFoc (mL/g)
1/n
Fr1,
Silty Clay
1.6
7.7
6.56-10.20
410-637
6.18
386
0.909
E1,
Loam
5.0
5.3
31.49-44.29
630-886
29.65
593
0.925
J1, Clay Loam
7.6
7.4
20.90-44.66
275-588
18.32
241
0.853
A1,
Loamy Sand
1.5
3.7
15.62-21.99
1070-1506
15.35
1051
0.917
E3, Silt Loam
2.9
5.5
20.52-30.50
720-1070
20.28
711
0.913
Geometric mean
NA
NA
16.0
528
NA
Arithmetic mean
23.9
774
18.0
596
0.903
Maximum
44.66
1506
29.65
1051
0.925
Minimum
6.56
275
6.18
241
0.853
pH dependence
No
The desorption coefficients, Kdes and Kdes,oc, were calculated for each soil at the highest test concentration. The values for the Freundlich desorption isotherm parameters KF, KFoc, and 1/n were derived from the linear form of the Freundlich equation. A summary of the desorption results for each soil is given in the following table.
Soil Type
OC
%
Soil pH
Kdes (mL/g)
K oc,des
(mL/g)
KF,des
(mL/g)
KFoc,des
(mL/g)
1/n
Fr1,
Silty Clay
1.6
7.7
10.77-15.65
673-978
7.87
492
0.916
E1,
Loam
5
5.3
47.00-64.72
940-1294
38.19
764
0.928
J1, Clay Loam
7.6
7.4
32.76-62.10
431- 817
23.12
304
0.859
A1,
Loamy Sand
1.5
3.7
26.03-33.43
1735-2229
27.29
1869
0.996
E3, Silt Loam
2.9
5.5
34.16-55.37
1178-1909
26.49
929
0.901
Geometric mean
NA
NA
21.9
724
NA
Arithmetic mean
36.5
1181
24.6
872
0.900
Maximum
64.72
2229
38.2
1869
0.996
Minimum
10.77
431
7.87
304
0.859
pH dependence
No
Based on the results of the study [14C]-myclobutanil was shown to have medium to low mobility in the soils tested. The Kd values for both adsorption and desorption were slightly higher at lower test item concentrations. No correlation was observed between the organic carbon content or pH of the test system and the Kd values.
Reference
Table 1: Adsorption coefficients
Soil | Kd (mL/g) | Koc (mL/g) | KF | KFOC | 1/n |
Fr1, Silty Clay | 6.56-10.20 | 410-637 | 6.18 | 386 | 0.909 |
E1, Loam | 31.49-44.29 | 630-886 | 29.65 | 593 | 0.925 |
J1, Clay Loam | 20.90-44.66 | 275-588 | 18.32 | 241 | 0.853 |
A1, Loamy Sand | 15.62-21.99 | 1070-1506 | 15.35 | 1051 | 0.917 |
E3, Silt Loam | 20.52-30.50 | 720-1070 | 20.28 | 711 | 0.913 |
Table 2: Desportion coefficients
Soil | Kdes (mL/g) | Koc,des (mL/g) | KF,des | KFOC, des | 1/n |
Fr1, Silty Clay | 10.77-15.65 | 673-978 | 7.87 | 492 | 0.916 |
E1, Loam | 47.00-64.72 | 940-1294 | 38.19 | 764 | 0.928 |
J1, Clay Loam | 32.76-62.10 | 431-817 | 23.12 | 304 | 0.859 |
A1, Loamy Sand | 26.03-33.43 | 1735-2229 | 27.29 | 1869 | 0.996 |
E3, Silt Loam | 34.16-55.37 | 1178-1909 | 26.49 | 929 | 0.901 |
Description of key information
In a GLP-study performed according to OECD TG 106, the arithmetic mean of the Koc-value of myclobutanil was calculated to be 774 at 20°C.
Key value for chemical safety assessment
- Koc at 20 °C:
- 774
Additional information
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