Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 266-719-9 | CAS number: 67564-91-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to terrestrial arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to terrestrial arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28.07.- 05.08.1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- according to guideline
- Guideline:
- other: EPPO 170, Side-effects on honeybees
- Version / remarks:
- 1992
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Test organisms (species):
- Apis mellifera
- Animal group:
- Hymenoptera (honeybees)
- Details on test organisms:
- TEST ORGANISM
- Common name: Honeybee
- Source: colonies from a breeding line of a commercial beekeeper in Baden-Württemberg, Germany
- Age at test initiation: approx. 22 - 32 days
- Cultural background (if honeybees): Apis mellifera carnica (Hymenoptera, Apidae)
- Disease free: yes, healthy colony - Study type:
- laboratory study
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 24°C - 29°C
- Humidity:
- relative humidity 50% - 75 %
- Photoperiod and lighting:
- 24 h darkness
- Details on test conditions:
- TEST SYSTEM
- Test container / cage (material, size): cages made of high grade steel (10 x 5.5 x 8.5 cm); frontside: transparent pane for observation; perforated board on the bottom (guaranteering sufficient air supply for the test insects
- Details of emergence and fecundity chambers:
- No. of organisms per container (treatment): 10 bees
- No. of replicates per treatment group: 5
EFFECT PARAMETERS MEASURED (with observation intervals if applicable):
LD50, (50% mortality of honeybees after exposure over 24 h or 48 h)
FOOD CONSUMPTION (if oral study)
- Starving before Test feeding: 2 hours 25 minutes
- Amount of treated diet consumed per group: offered amount of 250 µL per cage - Nominal and measured concentrations:
- nominal concentrations: Control, 6.25, 12.5, 25.0, 50.0, 100.0 µg a.s./bee; analysed: 95.7% (w/w)
- Reference substance (positive control):
- yes
- Remarks:
- Dimethoate (BAS 152 11; 400 g/L)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LD50
- Effect conc.:
- > 95.6 µg per animal
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Oral test
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LD50
- Effect conc.:
- > 100 µg per animal
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Contact test
- Details on results:
- In the oral toxicity test the maximum nominal test level of Fenpropimorph (100 µg a.s./bee) corresponded to an actual intake of 95.6 µg a.s./bee. Up to this concentration the corrected mortality did not exceed 21.7%.
In the contact toxicity test the corrected mortality did not exceed 2.0% at Fenpropimorph concentrations between 6.25 and 100 µg a.s./bee.
The LD50 of the test substance was determined to be > 95.6 µg a.s./bee in the oral test (48 h) and > 100 µg a.s./bee in the contact test (48 h). - Results with reference substance (positive control):
- The LD50 oral and LD50 contact of the active ingredient dimethoate was determined occasionally during the bee testing season in order to examine the variability of the bees used for the test.
- Conclusions:
- Toxicity of Fenpropimorph was tested in both an acute oral and a contact test on honeybees. The LD50 (48 h) was >100 µg a.s./bee in the contact toxicity test and >95.6 µg a.s./bee in the oral toxicity test.
Reference
Table 8.3/1 Toxicity of Fenpropimorph to honeybees (Apis mellifera carnica L.) in oral and contact toxicity | ||
| Oral test | Contact test |
|
|
|
Mortality | mortality did not exceed 21.7% at 95.6 µg a.s./bee | mortality did not exceed 2.0% at 100 µg a.s./bee |
Endpoints [µg a.s./bee] | ||
LD50 | > 95.6 | > 100 |
The reference substance showed a corrected mortality of 97.8% in the oral test (48 h) and of 56% in the contact test (48 h).
Description of key information
After 48 h, the oral toxicity test with Apis mellifera revealed an LD50 >95.6 µg/bee, the acute contact toxicity study an LD50 >100 µg/bee.
Key value for chemical safety assessment
Additional information
Key study (BASF, 1999/11450, 1999)
An acute contact toxicity study with fenpropimorph in honeybees (Apis mellifera) was conducted according to guideline EPPO 170 (1992). Toxicity of fenpropimorph was tested in both an acute oral and a contact test on honeybees. The honeybees were exposed to the following five test substance concentrations: 6.25, 12.5, 25.0, 50.0 and 100.00 µg/bee. The organisms were observed at 2, 4, 24 and 48 hours after application to determine their death rate. The LD50 (48 h) was >100 µg a.s./bee in the contact toxicity test and >95.6 µg a.s./bee in the oral toxicity test.
Additionally it shall be mentioned that in the publication ''Effects of pesticides on the reproduction of Hypoaspis aculeifer (Gamasida: Laelapidae) in the laboratory'' from the year 1995 from Paul H. Krogh the effects of fenpropimorph on the predacious mite H. aculeifer were investigated. During a test duration of 3 weeks a NOEC > 6.0 mg/kg was determined via a single species reproductive test system (no test guideline is available).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.