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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- mixture rules calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Remarks:
- Turmeric Leaf Oil is a Natural Complex Substance and UVCB with a well-defined composition for which the relative percentage is known. The acute oral toxicity has been investigated using constituent approach and CLP additivity calculation.
Data source
Reference
- Reference Type:
- other: Guidance
- Title:
- Guidance on the Application of the CLP Criteria - Guidance to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures
- Author:
- ECHA
- Year:
- 2 017
- Bibliographic source:
- ECHA-17-G-21-EN
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Classification based on calculation rules for mixtures of the CLP Regulation
- GLP compliance:
- not specified
- Remarks:
- Calculation method
Test material
- Reference substance name:
- Curcuma longa, essential oil obtained by steam distillation of the leaves
- Molecular formula:
- No applicable for UVCB substance
- IUPAC Name:
- Curcuma longa, essential oil obtained by steam distillation of the leaves
- Test material form:
- liquid
Constituent 1
Results and discussion
Effect levels
- Key result
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Calculated
Any other information on results incl. tables
Constituent | CAS# | Typical Concentration, % | rat oral LD50, mg/kg bw | C/ATE calculation | Reference |
ALPHA-PHELLANDRENE | 99-83-2 | 55.85 | 5700 | No category, not included for calculation | RIFM Reference No. 2536 |
TERPINOLENE | 586-62-9 | 11.33 | 3740 | No category, not included for calculation | REACH registration: https://echa.europa.eu/nl/registration-dossier/-/registered-dossier/10412/7/3/2 |
EUCALYPTOL | 470-82-6 | 6.6 | 4500 | No category, not included for calculation | REACH registration: https://echa.europa.eu/nl/registration-dossier/-/registered-dossier/13231/7/3/2 |
P-CYMENE | 99-87-6 | 5.93 | 4750 | No category, not included for calculation | Jenner et al., Food and Cosmetics Toxicology, 1964, 2, 327-343 |
MYRCENE | 123-35-3 | 3.17 | >5000 | No category, not included for calculation | REACH registration https://echa.europa.eu/nl/registration-dossier/-/registered-dossier/14795/7/3/2/ |
LIMONENE | 138-86-3 | 2.92 | >2000 | No category, not included for calculation | REACH registration: https://echa.europa.eu/nl/registration-dossier/-/registered-dossier/15256/7/3/2 |
ALPHA-PINENE | 80-56-8 | 2.72 | >500 | 0.00544 | REACH registration: https://echa.europa.eu/nl/registration-dossier/-/registered-dossier/14724/7/3/2 |
BETA-PINENE | 127-91-3 | 2.72 | >5000 | No category, not included for calculation | REACH registration: https://echa.europa.eu/nl/registration-dossier/-/registered-dossier/15934/7/3/2 |
GAMMA-TERPINENE | 99-85-4 | 2.33 | >2000 | No category, not included for calculation | RIFM Reference No. 2021 |
CARENE | 13466-78-9 | 1.2 | 4800 | No category, not included for calculation | RIFM Reference No. 2536 |
ALPHA-TERPINENE | 99-86-5 | 1.02 | 1680 | 0.000607143 | RIFM Reference No. 2021 |
Total | 95.79 | 0.006047143 |
ATEmix = 100 / 0.006047143 = 16537 mg/kg bw
Conclusion: LD50 >2000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Acute oral toxicity of the UVCB substance has been determined to be LD50 >2000 mg/kg bw by using the constituent approach and CLP additivity calculation.
- Executive summary:
Turmeric Leaf Oil is a Natrual Complex Substance and UVCB with well-defined composition. Its acute oral toxicity has been determined to be LD50 >2000 mg/kg bw by using the constituent approach and CLP additivity calculation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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