Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 604-636-5 | CAS number: 148477-71-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- In-life initiated/completed: 06-March-1997 to 03-July-1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Study conducted under GLP and in a trusted laboratory. Conducted to OECD Guidelines No. 105
corresponding to EC Guideline A.6 guidelines. - Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Principles of method if other than guideline:
- The water solubility of Spirodiclofen was determined at 20 °C at pH 4 according to the OECD Guidelines No. 105 corresponding to EC Guideline A.6 as described under column method. It was not possible to determine the solubility as a function of pH as the substance is rapidly hydrolysed at pH-values > 4 *). In order to prove that the saturation equilibrium had been reached, samples were drawn at two different flowrates.
Establishment of the solubility equilibrium and sample preparation:
A glass column containing the test substance deposited on Chromosorb as an inert support
material is connected by means of teflon tubes to a levelling vessel filled with water. The flow-rate is adjusted by means of a restriction capillary between the column and the levelling vessel. The concentration is measured in samples collected at two different flow-rates, a starting flow-rate, tentatively chosen and a lower one of approx. half the rate. If samples collected at the lower rate show a higher apparent solubility then the halving of the flow-rates must continue until the results of the concentration measurements from two series are in agreement. Only then the residence time of the water in the saturation column is sufficient for achieving solubility equilibrium.
In order to prepare the loaded support material portions of 5 g of Chromosorb W/AW were added to a solution of approx. 0.5 g of test substance. The solvent of the resulting suspension was completely evaporated using a rotary evaporator. Residues of solvent were removed overnight in a desiccator connected to a rotary slide-valve oil pump.
The loaded support material was suspended in water and transferred into the glass elution columns (inner diameter 1.2 cm) by rinsing with water. The particles of the loaded Chromosorb settled to form a column bed approx. 35 cm long. The column was connected by means of teflon tubing to a levelling vessel filled with water.
The elution column was placed vertically in a large water-bath thermostated at 20 °C ± 0.5 °C and the stopcock between levelling vessel and restriction capillary was opened. The flow-rate of the effluent from the saturation column was determined by collecting it in measuring flasks.
The test substance tends to be adsorbed on the inner glass surface of the sample bottles. To keep the substance in solution the weight amounts of the collected effluents were added with calculated volumes of acetonitrile producing a concentration of 20% (neglecting volume contraction).
In order to vary the flow-rate capillaries of different length were introduced into the teflon tubing above the column. Afterwards the pH of the water was changed by substitution of the water in the levelling vessel by different buffer.
The effluent was directed into the waste for 40 mins. before a fraction was collected during a time period of 20 mins.and 8 mins, respectively. The concentration of the test substance in this clear fractions was directly measured by means of the HPLC method. - GLP compliance:
- yes
- Type of method:
- column elution method
- Key result
- Water solubility:
- 49.7 µg/L
- Temp.:
- 20 °C
- pH:
- 4.08
- Key result
- Water solubility:
- 50.6 µg/L
- Temp.:
- 20 °C
- pH:
- 4.08
- Conclusions:
- The substance is considered effectively insoluble in water for purposes of the chemical safety assessment. At pH >4, hydrolysis will occur with a half life of ca 30 days at pH7.
- Executive summary:
The water solubility of Spirodiclofen is 50 µg/L in buffered aqueous solutions at pH 4 and 20 °C. Water solubilities for the pH range between 4 and 9 cannot be determined due to the instability of the substance.
Reference
Table. 1 Water solubility - Summary of results
acidic citrate buffer c(C6H807xH20) | = 0.01 Mole/L | adjusted to pH 4 with cone. NaOH | ||
pH | 4.08 | 4.08 | ||
eluation column flow rate (ml/h) | 26.4 - 28.0 | 41.5-43.0 | ||
code | µg/l | code | µg/l | |
9230200 | 50.2 | 9230210 | 49.2 | |
9230201 | 51.1 | 9230211 | 49.3 | |
9230202 | 51.3 | 9230212 | 50.5 | |
9230203 | 51.0 | 9230213 | 50.5 | |
9230204 | 51.2 | 9230214 | 50.1 | |
9230205 | 50.7 | 9230215 | 50.4 | |
9230206 | 51.5 | 9230216 | 48.7 | |
9230207 | 51.3 | 9230217 | 49.5 | |
9230208 | 48.8 | 9230218 | 49.5 | |
9230209 | 49.3 | 9230219 | 48.9 | |
mean | 50.6 | 49.7 | ||
rel. standard deviation | 1.80 | 1.34 |
Description of key information
The water solubility of Spirodiclofen is 50 µg/L in buffered aqueous solutions at pH 4 and 20 °C. Water solubilities for the pH range between 4 and 9 cannot be determined due to the instability of the substance.
Key value for chemical safety assessment
- Water solubility:
- 50 µg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.