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Endpoint summary

Description of key information

Hydrolysis

 

Analytical monitoring of the test tem in the aqueous puffer solutions used for tha hydrolysis studie according to the guideline OECD 111 is not possible due to the low water solubility of the test item and high analytical detection limit / low sensitivity of the analytical method.

 

No test item could be detected in aqueous samples of aquatoxicity studies (Noack ID: 180706CM / DAI18315 and SPO18315) when test samples were prepared as water accommodated fractions (WAF). Only approximately 0.1 to 1 mg test item/L can be detected though a LC-MS/MS system, known as analytical device enabling the implementation of analytical methods with highest sensitivity. Furthermore, no stock solutions of the test item, for application into an aqueous phases, in concentrations adequate for analytical monitoring can be prepared. Only 50 mg test item/L can be dissolved in toluene under heating (Noack ID: 180706CM / CAD18315N) and this solution is unsuitable for aqueous spiking.

 

In combination, these facts impair the accurate deduction of the study endpoints required by the guideline OECD111, as a reliable and sensitive quantitation of the test item in the aqueous buffer solutions during the experiments is mandatory for their calculation. The low water solubility, the low sensitivity of the analytical method and the the lack of suitable solvents for the praparation of stock solutions for spiking of aqueous solutions, led to the assessmet, that a hydrolysis study according to OECD guideline 111 is technically not feasible.

 

 

 

The experimental determination of the hydrolysis as a function of pH of
LICOCARE RBW 300 FL TP
according to the OECD guideline OECD 111 is

 

Technically not Feasible.

 

Biodegradation

 

In an enhanced CO2 Evolu6tion test according to OECD 301 B it could be shown that the test substance is readily biodegradable but failed the 10 day windows. After 28 days the biodegradation was 71.1 % and after 60 days 92.8 %

Under the conditions of the study, percentage biodegradation of the test substance at the end of the test over 60 days was 92.8%, greater than 60%, therefore the test substance can be considered not to be persistent.

In two inherent test according OECD 302 C, after 28 days of incubation, the test item was degradable to 83.5% (mean value) respectively 64 % based on BOD-measurement. Therefore the test item is also inherently biodegradable.

 

Adsoprtion / Desorption

 

Analytical monitoring of the test tem in the aqueous phase of soil suspensions used in an adsorption / desorption study according to the guideline OECD 106 is not possible due to the low water solubility of the test item and high analytical detection limit / low sensitivity of the analytical method.