Registration Dossier
Registration Dossier
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EC number: 940-437-2 | CAS number: 926-50-1
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 8 April to 31 May 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 10.3 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 25 g/L
- Incubation duration:
- 17 d
- Temp.:
- 20 °C
- pH:
- ca. 4.2 - ca. 4.3
- Executive summary:
The solubility of the test item in pure water was determined according to the OECD Guideline No. 105 (flask method), and under GLP.
With the standard test procedure, the phase separation could not be adequately achieved (>15% deviation between the individual results). Therefore an alternative method (saturation equilibrium method) was preferred, with sampling from the bottom. The test was conducted in duplicate, with GC-FID analysis after 3, 7, 12 and 17 days of contact time.
Equilibrium was considered achieved from 7 days (< 15% deviation), so the water solubility was calculated as the average of the concentrations measured on days 7, 12 and 17.
The solubility of the test item in water is 10.3 g/L (20 °C, pH 4.2 - 4.3).
Reference
The solubility in ultrapure water was calculated from the analytical concentrations obtained in the analyses are tabulated below. The individual results obtained on days 7, 12 and 17 do not differ by more than 15 %, as required for this method by the OECD 105 guideline.
The results obtained on day 3 not used for the calculation of the water solubility, as it can be concluded that saturation of the aqueous phase was not yet attained. At test end the pH values of the solutions in ultrapure water was pH 4.2 and pH 4.3 on two independent flasks.
Table 4.8/1: Solubility of test item
Contact time |
3 |
7 |
12 |
17 |
Average day 7-17 |
Concentration (g/L) |
7.6 |
10.1 |
10.8 |
10.2 |
10.3 |
Description of key information
Considered as very soluble in water.
Key value for chemical safety assessment
- Water solubility:
- 10.3 g/L
- at the temperature of:
- 20 °C
Additional information
A fully reliable experimental study, conducted according to a recognized OECD method and under GLP, is available.
It is considered as a key study; the result is retained as key data for CSA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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