p-nitrophenyl dihydrogen phosphate, compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:2)

Flash point

Administrative data

Endpoint:

flash point of flammable liquids

Data waiving:

study technically not feasible

Justification for data waiving:

the study does not need to be conducted because the flash point is only relevant to liquids and low melting point solids

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

13-26 August 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Version / remarks:

1998

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

EC No. 440/2008

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

1995

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

Batch No.: 46587100
Storage: Refrigerator (approx. 2-8°C)

Key result

Melting / freezing pt.:

>= 162 - <= 163 °C

Atm. press.:

>= 1 002 - <= 1 004 hPa

Decomposition:

yes

Decomp. temp.:

ca. 210 °C

During the heating phase a distinct endothermic effect was observed in the temperature range of 150-180°C, which can be assigned to the melting of the test item. The endothermic effect was directly followed by a small exothermic effect starting at a temperature of approx. 180°C with an average energy release of -20 J/g.

As the onset temperatures in both tests deviate by more than 0.5 K from their mean value of 162.51 °C, the test item has a melting range of 162-163°C.

A second exothermic effect was observed starting at a temperature of approx. 220°C with an average energy release of -290 J/g.

Measurement No.	Sample weight / mg	Onset of Effect / °C	Range of effect / °C	Weight loss / mg	Atmospheric pressure / hPa
PN20063	7.72	163.23 --- ---	150 – 180 (endo) 180 – 190 (exo) 220 – 340 (exo)	3.86	1001.8
PN20065	9.53	161.78 --- ---	150 – 180 (endo) 180 – 190 (exo) 220 – 330 (exo)	4.57	1003.6

Optical verification using the capillary method

To verify the results of the DSC measurement, an additional measurement in a melting capillary was performed in the temperature range of 27°C to 225°C with a heating rate of 10 K/min. The test item started to melt at a temperature of approx. 140°C. At a temperature of 165°C the test item was completely molten (dark yellow liquid). At a temperature of 210°C the colour of the test item changed to orange. At a temperature of 225 °C the test item turned brown and rose inside the capillary. The test was terminated at a maximum temperature of 225 °C.

According to the observations during the test in the capillary method, the endothermic effect in the DSC measurements with open crucibles can be assigned to the melting of the test item.

Conclusions:

The test item 4-NPP, di-TRIS (CAS no. 68189-42-4) has a melting range of 162-163°C at atmospheric pressure (1002-1004 hPa) as determined by Differential Scanning Calorimetry and capillary method according to Regulation (EC) No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995).

Executive summary:

The test item 4-NPP, di-TRIS (CAS no. 68189-42-4) has a melting range of 162-163°C at atmospheric pressure (1002-1004 hPa) as determined by Differential Scanning Calorimetry and capillary method according to Regulation (EC) No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995).