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Diss Factsheets
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EC number: 256-275-4 | CAS number: 46728-75-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Data Reported: 21 September 1979
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Justification for type of information:
- Weight of Evidence: The test result is reported without adequate documentation to fully judge its reliability. However, when coupled with data from a second species, its reliability and usefulness for classification and labeling is enhanced.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- Documentation insufficient to fully judge reliability.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Lithium dihydrogen 5-sulphonatoisophthalate
- EC Number:
- 256-275-4
- EC Name:
- Lithium dihydrogen 5-sulphonatoisophthalate
- Cas Number:
- 46728-75-0
- Molecular formula:
- C8H6O7S.Li
- IUPAC Name:
- lithium dihydrogen 5-sulphonatoisophthalate
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Moisture content:
6.5%
- Colour: Off-white
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No information reported.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Rats were given 10% aqueous solutions of the test substance via gavage.
- Doses:
- Reported as: 200 - 3200 mg/kg-bw. No intermediate dose was reported but is presumed to have been 800 mg/kg with a 0 mg/kg control group; giving presumed doses of 0, 200, 800, and 3200 mg/kg-bw.
- No. of animals per sex per dose:
- In total, 20 animals are reported but the number of animals per dose is not reported. Given the presumed doses of 0, 200, 800, and 3200 mg/kg-bw, it is presumed there were 5 animals per dose.
- Control animals:
- other: Not specified but presumed yes.
- Remarks:
- See above discussion on doses and animals per dose.
- Statistics:
- Not specified.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- approximate LD50
- Effect level:
- 2 262 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Numbers not reported. Time of death reported to be 1-2 days.
- Clinical signs:
- Normal to slight weakness and quite in low doses. Lethargic with diarrhea and one animal moribund in the high dose.
- Body weight:
- Positive weight change reported after 2 weeks.
- Gross pathology:
- No information reported.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The test substance is reported to have an Oral LD50 in rats of 2262 mg/kg-bw.
- Executive summary:
In a non-GLP study performed in a manner similar to OECD 401, the test substance was found to have an Oral LD50 in rats of 2262 mg/kg-bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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