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EC number: 847-973-5 | CAS number: 2363126-51-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Version / remarks:
- 17 December 2001
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 bis (Acute Oral Toxicity - Fixed Dose Procedure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Version / remarks:
- 712-C-02-190. December 2002
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Japanese Ministry of Agriculture, Forestry and Fisheries, Test Data for Registration of Agricultural Chemicals, Acute oral toxicity (2-1-1), 12 Nousan No 8147,
- Version / remarks:
- November 24, 2000.
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Iron(III) manganese(II) hexacyanoferrate(II) sodium salts
- EC Number:
- 847-973-5
- Cas Number:
- 2363126-51-4
- Molecular formula:
- NaxMny1Fey2[Fe(CN)6]z X = 1-2; Y1 = 0.5-0.9; Y2 = 0.1-0.5; Z = 0.67-1.0
- IUPAC Name:
- Iron(III) manganese(II) hexacyanoferrate(II) sodium salts
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- Water
- Test material form:
- solid: particulate/powder
Constituent 1
impurity 1
- Specific details on test material used for the study:
- See section "Test material information""
Test animals
- Species:
- rat
- Strain:
- other: RccHan™:WIST albino
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Rationale for alternative/additional species to rat (if applicable): not applicable
- Source: Envigo RMS (UK) Ltd
- Females (if applicable) nulliparous and non-pregnant: [yes]
- Rationale for use of males (if applicable): not applicable
- Age at study initiation: eight to twelve weeks of age
- Weight at study initiation: 154 to 181 g
- Fasting period before study: overnight prior to dosing
- Housing: solid bottomed polycarbonate cages with a stainless steel mesh lid. Each cage contained a quantity of autoclaved softwood bark-free fiber bedding. Cages, food hoppers, water bottles and bedding were changed at appropriate intervals.
- Diet (e.g. ad libitum): ad libitum, Teklad 2014C Diet
- Water (e.g. ad libitum): ad libitum, Potable water taken from the public supply
- Acclimation period: not specified
- Microbiological status when known: not specified
- Method of randomisation in assigning animals to test and control groups: not specified
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 to 24°C
- Humidity (%): 40 to 70%
- Air changes (per hr): not specified
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: Sighting study: 300 + 2497 mg/kg anhydrous test substance in Corn Oil; Main study: 5 mg/kg anhydrous test substance in Corn Oil
- Amount of vehicle (if gavage): 10 mL/kg
- Justification for choice of vehicle:
- Lot/batch no. (if required):
- Purity:
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
DOSAGE PREPARATION (if unusual): not applicable - Doses:
- Range finder: 300 mg/kg
Main study: 2000 mg/kg - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days (or other?)
14 d
- Frequency of observations and weighing:
d 0, 1, 8 and 15
- Necropsy of survivors performed: yes
: Subcutaneous tissue, Brain, Heart, Lungs and bronchi, Liver, Spleen, Kidneys, Stomach, Duodenum, Small Intestines, Large Intestines, Cecum, Urinary Bladder
- Clinical signs including body weight: Unsteady gait, Decreased activity, Irregular breathing, Convulsion, Flattened posture, Rapid breathing, Shallow breathing, Prostrate posture, Unresponsive behavior
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: yes
Results and discussion
- Preliminary study:
- There were no deaths during the study.
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks:
- anhydrous content
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- There were no deaths during the study.
- Clinical signs:
- other: Black feces were observed in all females dosed at 2000 mg/kg in the main study. This sign was observed on Day 2 of the study. Recovery of this clinical sign, as judged by external appearance and behaviour, was complete by Day 3. No clinical signs were see
- Gross pathology:
- No abnormalities were noted in any animal at the macroscopic examination at study termination on Day 15.
- Other findings:
- not reported
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The acute median lethal oral dose (LD50) to rats of the test item was demonstrated to be greater than 2497 mg/kg body weight (equivalent to 2000 mg/kg anhydrous test item).
The test item is therefore included in Category 5, according to the Globally Harmonised System (GHS). - Executive summary:
The study was performed to assess the acute oral toxicity of the test item, an industrial chemical, to the rat.
Fasted female rats received a single oral gavage dose of the test item, formulated in corn oil, at the following dose levels:
- Sighting investigations: 375* and 2497** mg/kg body weight.
- Main study: Based on the results of the sighting investigations a further four fasted females were similarly dosed at 2497** mg/kg body weight.
* 375 mg/kg was the test item as supplied which was equivalent to 300 mg/kg of the anhydrous test item.
** 2497 mg/kg was the test item as supplied which was equivalent to 2000 mg/kg of the anhydrous test item.
During the study, clinical condition, body weight and macropathology investigations were undertaken.
Results
There were no deaths during the study.
Black feces were observed in all females dosed at 2497 mg/kg in the main study. This sign was observed on Day 2 of the study. Recovery of this clinical sign, as judged by external appearance and behaviour, was complete by Day 3. No clinical signs were seen in any other animal dosed at 375 mg/kg (sighting study 1) or 2497 mg/kg (sighting study 2).
A low body weight gain was observed on Day 8 to 15 for female number 82 dosed at 2497 mg/kg in sighting study 2 and female number 83 dosed in the main study at 2497 mg/kg. All other animals were considered to have achieved satisfactory body weight gains throughout the study.
No abnormalities were noted in any animal at the macroscopic examination at study termination on Day 15
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