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EC number: 225-969-9 | CAS number: 5188-07-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- SIDS Dossier
- Author:
- OECD
- Year:
- 2 008
- Bibliographic source:
- OECD SIDS Dossier - sodium methanethiolate
- Reference Type:
- other: Unpublished study report
- Title:
- Acute dermal toxicity in rats. CIT Report No. 10874.
- Author:
- Elf Atochem
- Year:
- 1 994
- Bibliographic source:
- as cited in Methanethiol/sodium methanethiolate, OECD SIDS Initial Assessment Report For SIAM 27, 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- adopted 1987
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium methanethiolate
- EC Number:
- 225-969-9
- EC Name:
- Sodium methanethiolate
- Cas Number:
- 5188-07-8
- Molecular formula:
- CH4S.Na
- IUPAC Name:
- sodium methylsulfanide
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Test article name : Sodium methylmercaptide
- CAS No.: 5188-07-8
- Origin: Elf Aquitaine, Lacq
- Batch: 93-7074
- Composition: Sodium methylmercaptide: 21.2 % (w/w) in water, free NaOH: 1.0% (w/w)
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Duration of exposure:
- 24 hours
- Doses:
- First assay: 2000 mg/kg bw (424 mg/kg bw raw material)
Second assay: 400 mg/kg bw (84.8 mg/kg bw raw material) - No. of animals per sex per dose:
- At 2000 mg/kg bw: 1 per sex
At 400 mg/kg bw: 4 per sex - Control animals:
- no
- Details on study design:
- Sodium methylmercaptide (21.2% solution in water) was administered by dermal route to a group of Sprague-Dawley rats. As the test substance was anticipated to be corrosive, 1 animal per sex were used in a first assay. The test substance in its original form was applied directly to the skin at a dose of 2000 mg/kg bw (i.e. 424 mg/kg bw in raw material), taking into consideration that the specific gravity (SG) of the test substance was 1.12. In a second assay, 8 animals (4 males and 4 females) were treated with the test substance at a dose of 400 mg/kg bw (i.e. 84.8 mg/kg in raw material). After 24 hours under a semi-occlusive dressing, no residual test substance was observed on removal of the dressing. The animals given 400 mg/kg bw were checked for clinical signs, mortality and body weight gain for a period of 14 days following the single application of the test substance. A necropsy was performed on each animal sacrificed during the study or sacrificed at the end of the study.
- Statistics:
- not specified
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 84.8 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: recalculated to 100% raw material
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 400 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other:
- Remarks:
- formulated test substance: 21.2% in water
- Mortality:
- At 2000 mg/kg bw (424 mg/kg bw raw material) the 2 treated animals were sacrificed on day 2 for humane reasons. At 400 mg/kg (84.8 mg/kg bw raw material) bw no deaths were noted.
- Clinical signs:
- At 2000 mg/kg bw tissue lesions on the whole depth of the skin were noted after removal of the dressing on day 2. At 400 mg/kg bw no cutaneous reactions were noted in males and females. Hypoactivity, tremors were noted in one female. No clinical signs and no alteration of the general behaviour were noted in the other animals.
- Body weight:
- At 400 mg/kg bw reversible body weight loss between days 1 and 5 was noted in one female.
- Gross pathology:
- n.a.
- Other findings:
- n.a.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Based on the results from an acute dermal toxicity study, the dermal LD0 value was determined to be > 84.8 mg/kg bw.
- Executive summary:
In an acute dermal toxicity study (OECD 402), Sprague-Dawley rats (1/sex) were applied a single dermal dose of 2000 mg/kg bw of Sodium methanethiolate (21.2% solution in water, equalling 424 mg/kg bw raw material). In addition, eight animals (4/sex) were treated with a single dermal dose of 400 mg/kg (i.e. 84.8 mg/kg bw raw material). After treatment the animals were observed for 14 days. At 2000 mg/kg bw, tissue lesions on the whole depth of the skin were noted after removal of the dressing on day 2. The two treated animals were sacrificed on day 2 for humane reasons. At 400 mg/kg bw, no cutaneous reactions and no deaths were noted. Hypoactivity, tremors and reversible body weight loss between days 1 and 5 were noted in one female. No clinical signs and no alteration of the general behaviour were noted in the other animals.
Based on the results, the dermal LD0 was determined to be > 400 mg/kg bw and after recalculation towards the pure substance, the dermal LD0 can be considered to be > 84.8 mg/kg bw.
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