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EC number: 210-719-3 | CAS number: 622-08-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
- Version / remarks:
- 2015
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Batch 170808-29
Exp Date 28/08/2019
Assay > 99% - Test system:
- human skin model
- Source species:
- human
- Cell type:
- non-transformed keratinocytes
- Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
- Amount/concentration applied:
- TEST MATERIAL
16 +/- 0,5 mcl
NEGATIVE CONTROL
16 +/- 0,5 mcl
POSITIVE CONTROL
16 +/- 0,5 mcl - Duration of treatment / exposure:
- 42 h
- Number of replicates:
- 3
- Irritation / corrosion parameter:
- % tissue viability
- Value:
- ca. 68.5
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to OECD 439:2015, under the test conditions applied, the test substance is considered NON IRRITANT
- Executive summary:
The test was carried out using reconstructed human epidermis (RHE), in triplicate. The exposure of the insert to the test substance was carried out for 42 in at room temperature.
After treatment the inserts were rinsed with D-PBS and post-incubated with growth medium for additional 42 hours at 37 +/- 1°C, 5 +/-% CO2. Finally, inserts were incubated with MTT solution in oredr to evaluate cell viability which is a direct measure of the irritant potential of the substance. Because of the MTT - reducing interference produced by the test substance, additional testing were performed to evaluate the correct irrititant potential. Under these conditions, the test substance Benzyl Glycol CAS 622 -08 -2 assay >99% resulted NON IRRITANT
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 492 (Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage)
- Version / remarks:
- 2018
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- human
- Controls:
- yes, concurrent no treatment
- yes, concurrent negative control
- Irritation parameter:
- other: TISSUE VIABILITY
- Value:
- ca. 4.04
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Under the test method and test conditions employed the tissues treated with test item benzyl glycol showed a relative percent viability < 60 % hence, it is concluded that the test item was Irritant. According to the test method , the test substance is considered as requiring further testing for resolving between UN GHS categories 1 and 2.
- Executive summary:
The test substance Benzyl Glycok CAS 622 -08 -2 Assay > 99% was subjected to occular irritation assay, conducted according to OECD 492:2018. The test was carried out using Reconstructed human cornea-like Epithelium (RhCE), in duplicate. The exposure of the insert to the test substance was carried out for 30 minutes at 37 +/- 1°C, 5 +/- 1% CO2. After treatment the inserts were rinsed with D-PBS and incubated for 12 minutes at room temperature. Then the inserts were post incubated with assay medium for addtional 120 minutes at 37 +/- 1°C, 5 +/- 1% CO2. Finally, insertes were incubated with MTT solution in order to evaluate cell viability which is a direct measure of the irritant potential of the test substance. Under these conditions, the test substance is identified as requiring further testing for resolving between UN GHs Cat 1 and 2)
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Justification for classification or non-classification
According to OECD 439:2015, under the test conditions applied, the test substance is NOT considered SKIN IRRITANT.
Under the test method OECD 492:2018 and test conditions , it is concluded that the test item was Irritant.
According to the test method , the test substance is considered as requiring further testing for resolving between UN GHS categories 1 and 2.
Basing on the result of the test according to OECD 439; on that the substance ha not an extreme pH (from 6 to 8) the substance is classifed as EYE IRRITANT (GHS category 2).
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