Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
Reaction mass of tetrasodium 5-{[4-chloro-6-(4-{[2-(sulfonatooxy)ethyl]sulfonyl}anilino)-1,3,5-triazin-2-yl]amino}-4-hydroxy-3-[(4-{[2-(sulfonatooxy)ethyl]sulfonyl}phenyl) diazenyl]naphthalene-2,7-disulfonate and trisodium 5-({4-chloro-6-[4-(vinylsulfonyl) anilino]-1,3,5-triazin-2-yl}amino)-4-hydroxy-3-[(4-{[2-(sulfonatooxy)ethyl]sulfonyl}phenyl)diazenyl]naphthalene-2,7-disulfonate
EC number: 701-360-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 October 1989 to 01 March 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 84/449/EWG, appendix V
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Water solubility:
- > 200 g/L
- Temp.:
- 30 °C
- pH:
- 1.9 - 2.4
- Details on results:
- - Quality of the water: after demineralisation the water was distilled
- Water volume added to the weighed amounts of the test substance: 50 ml
- Duration of equilibration at 20 °C after stirring different times at 30 °C: 24 h
After centrifugation of charges no 1 -3 no excess solid was existing. The “solutions” were very thick and viscous. From the weighed portions and the added water a water solubility of ≥ 700 g/L can be calculated.
Further experiments
Also amounts of 25.3 and 28.2 g of the test substance added to 25 ml water (stirring time: 20.5 h at 30 °C; 3 h at 20 °C) showed no sediments (solubility > 1000 g/L).
Further experiments with the following amounts were carried out:
4) 56.4 g test substance in 50 ml water
5) 56.7 g test substance in 50 ml water
6) 56.3 g test substance in 50 ml water
7) 60.4 g test substance in 50 ml water
Stirring time: 44 h at 30 °C, 3 h at 20 °C
After centrifugation undissolved particles could be recognized in the charges 5 and 7. It was impossible to stir these samples equally. The “solutions" were such high viscous that it was not possible to take aliquots using a pipette.
Due to the experiments described above the experiments for the determination of the water solubility were repeated with smaller amounts.
Water volume added to the weighed portions of the test substance: 50 ml
During of equilibration at 20 °C after stirring different times at 30 °C: 24 h
The results of the experiments 8-10 and 11-13 obtained by photometric determination are clearly below the results obtained from a direct calculation from the weighed portions, water volume and content of the main component even though there was no residue.
Due to the experimental difficulties (no residue in exp. 1-3, very thick and high viscous and dark solutions) as a final result a minimum water solubility > 200 g/L is given (refer exp. 11 - 13). - Conclusions:
- The minimum water solubility of the test substance at 30 °C, applied to a content of 71.2 %, is > 200 g/L
- Executive summary:
Study conducted to 84/449/EWG, appendix V, part A, in compliance with GLP using the "Flask Method" - determined following the preliminary visual experiments.
The minimum water solubility of the test substance at 30 °C, applied to a content of 71.2%, is > 200 g/L
Reference
Table 1
Sample (no.) |
Amount test substance [g] |
Stirring time at 30°C [h] |
pH-value |
Test substance concentration (g/L) (photometric) |
1 |
35.5 |
24 |
*) |
*) |
2 |
35.5 |
48 |
*) |
*) |
3 |
35.2 |
72 |
*) |
*) |
*) not determined
Table 2
Sample (no.) |
Amount test substance [g] |
Stirring time at 30 °C [h] |
pH-value |
Test substance concentration (g/L) (photometric) |
8 |
26.7 |
24 |
2.2 |
429.2 |
9 |
26.9 |
48 |
2.1 |
431.3 |
10 |
27.6 |
72 |
1.9 |
434.0 |
|
|
|
Mean value |
431.5 |
Table 3
Experiment |
Concentration calc. from weighed portion and added water volume (g/L) |
Concentration converted under the premise of a content of 71.2% (g/L) |
8 |
535.0 |
380.9 |
9 |
538.8 |
383.6 |
10 |
552.2 |
393.2 |
Mean: |
542 |
386 |
Table 4
Sample (no.) |
Amount test substance [g] |
Stirring time at 30°C [h] |
pH-value |
Test substance concentration (g/L) (photometric) |
11 |
20.1 |
24 |
2.4 |
345.8 |
12 |
20.1 |
48 |
2.3 |
345.8 |
13 |
20.1 |
72 |
2.2 |
344.5 |
|
|
|
Mean value |
345.4 |
Table 5
Experiment |
Concentration calc. from weighed portion and added water volume (g/L) |
Concentration converted under the premise of a content of 71.2% (g/L) |
11 |
402.4 |
286.5 |
12 |
402.3 |
286.4 |
13 |
402.6 |
286.7 |
Mean |
402 |
287 |
There was no sediment to recognise and no residue in the filter.
Table 6
Experiment |
Concentration calc. from the weighed portion and volume H2O |
Concentration calc. from photometry |
||
Directly calculated |
Converted to 71.2% |
|
Converted to 71.2% |
|
(g/L) |
(g/L) |
(g/L) |
(g/L) |
|
1 – 3 |
≥700 |
≥498 |
--- |
--- |
8 – 10 |
542 |
386 |
432 |
308 |
11 – 13 |
402 |
287 |
345 |
246 |
Description of key information
Water solubility >200 g/L at 30°C
Key value for chemical safety assessment
Additional information
The minimum water solubility cS of the test item at a temperature of 30 °C was determined (corrected for purity). The water solubility of the test substance was > 200 °C (cS > 200 g/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.