[No public or meaningful name is available]

Auto flammability

Administrative data

Endpoint:

relative self-ignition temperature (solids)

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

See further information in the cross-ref.

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

self-heating substances / mixtures

Type of information:

experimental study

Adequacy of study:

key study

Study period:

10 - 28 November 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: The Grewer Oven test (VDI guideline 2263, part l , l990, Test methods for the Determination o f the Safety Characteristics of Dusts)

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: UN Recommendations on the transport of dangerous goods: manual of Tests and Criteria, Rev. 6 (2015), UN Division 4.2 Test N.4

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Specific details on test material used for the study:

Batch No.: 1000146/01
Storage Conditions: Freezer (approx. -15 °C)

Test procedure:

100 mm sample cube at 140°C

Max. temp. reached:

154

Induction time (h):

2

Result:

negative outcome (no effect observed)

Remarks:

After the sample maximum of 154°C, the temperature decreased to 140°C. Afterwards, the temperature in the centre of the sample did not exceed the oven temperature within a storage time of 34 hours

Grewer oven test

In the investigation of self-ignition in the Grewer Oven for the pure test item, first a small endothermic effect could be observed at a temperature of 110°C which results into an exothermic effect at approximately 120°C. This effect leads to a temperature increase up to 144°C (corresponding temperature of the reference material was 134°C). In the temperature range of 150-230°C several small endothermic effects could be observed. At a temperature of 240°C a multi-stage self-ignition could be observed with a maximum temperature of 600°C. A black residue remained in the wire basket after the test. For the test item in mixture with Kieselguhr, first a small endothermic process was detected starting at 110°C. A weak exothermic effect could be observed at a temperature of 150°C. Several weak endothermic and exothermic effects could be observed in the temperatrue range of 190-250°C. At a temperature of 250°C a multi-stage self-ignition could be observed with a maximum temperature of 425°C (corresponding temperature of the reference material was 413°C).

Bowes-Cameron-Cage Test

The temperature in the centre of the sample (100 mm cube with a weighed mass of 398.7g at an oven temperature of 140°C) exceeded the oven temperature to a maximum temperature of approx. 154°C (temperature difference between oven temperature and sample temperature 14K) within approximately 2 hours test time. After the sample temperature maximum of 154°C the temperature decreased to 140°C. Afterwards, the temperature in the centre of the sample did not exceed the oven temperature within a storage time of 34 hours.

Since the temperature increase is below the treshold of 60K withing 24 hours the result of the test is negative. Due to the negative result in the 100 mm cube sample at an oven temperature of 140°C, further tests do not have to be performed.

In conclusion, the test in the 100 mm cube sample at 140°C showed no self-heating of the test item with a temperature increase of >60K within 24 hours. According to the results of the test on the self-heating in the Bowes-Cameron-Cage Test (UN Test N.4) the test item should not be classified as self-heating in class 4, division 4.2 according to the UN Transport Regulation or according to the GHS/CLP Regulation EC 1272/2008 Annex 1:2.11.

Interpretation of results:

not classified based on GHS criteria

Conclusions:

According to the results of the test on the self-heating in the Bowes-Cameron-Cage Test (UN Test N.4) the test item Nicotinamide-beta-D-riboside bromide (CAS no. 78687-39-5) should not be classified as self-heating in class 4, division 4.2 according to the UN Transport Regulation or according to the GHS/CLP Regulation EC 1272/2008 Annex 1:2.11.

Executive summary:

The test in the 100 mm cube sample at 140 °C showed no self-heating of the test item Nicotinamide-beta-D-riboside bromide (CAS no. 78687-39-5) with a temperature increase of > 60 K within 24 hours.

Accordingto the results of the test on the self-heating in the Bowes-Cameron-Cage Test (UN-Test N.4) the test item Nicotinamide-beta-D-riboside bromide(CAS no.78687-39-5) is classified as follows:

UN Transport Regulation: The test item should not be classified as self-heatingsubstance in class 4, division 4.2 according to the UN Transport Regulation

GHS / CLP RegulationEC 1272/2008 Annex1: 2.11: The test item should not be classified as self-heating substance according to GHS/CLP RegulationEC 1272/2008 Annex 1: 2.11