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Diss Factsheets
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EC number: 214-379-7 | CAS number: 1123-85-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A human patch test with 25 healthy adult volunteers was performed as described in J.I.D., Vol 47; No. 5; 393-409; 1966 by A.M. Kligman et al.
- GLP compliance:
- no
- Remarks:
- pre-dates GLP
- Type of study:
- patch test
- Justification for non-LLNA method:
- study was available
Test material
- Reference substance name:
- 2-phenylpropan-1-ol
- EC Number:
- 214-379-7
- EC Name:
- 2-phenylpropan-1-ol
- Cas Number:
- 1123-85-9
- Molecular formula:
- C9H12O
- IUPAC Name:
- 2-phenylpropan-1-ol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Hydratropic alcohol as supplied was used, purity >95%, technical grade.
In vivo test system
Test animals
- Species:
- other: human volunteers
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals and environmental conditions:
- Twenty five (25) healthy adult human volunteers completed the experiment.
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- 100%
- Day(s)/duration:
- five alternate days 48 hours period
- Adequacy of induction:
- other: non-irritat substance, but skin pre-treated with 5% aqueous sodium lauryl sulfate (SLS) under occlusion.
Challenge
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- 100%
- Day(s)/duration:
- on removal of patch and 24 hours thereafter
- Adequacy of challenge:
- highest non-irritant concentration
- No. of animals per dose:
- 24 adult healthy volunteers completed the study (13 males and 11 females)
- Details on study design:
- The material was pre-tested on five subjects in order to determine whether sodium lauryl sulfate (SLS) pre-treatment was required. A patch of this material was applied to normal sites on the backs for 48 hours under occlusion. No subject had any irritation from this material and it was decided to use SLS pre-treatment in the test.
The material was applied under occlusion to the same site on the volar forearms of all subjects for five alternate-day 48 hour periods. The patch site was pre-treated for 24 hours with 5% aqueous sodium lauryl sulftae under occlusion.
The challenge sites were read on removal of the patch and 24 hours thereafter. - Positive control substance(s):
- no
Results and discussion
- Positive control results:
- not applicable
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 100%
- No. with + reactions:
- 0
- Total no. in group:
- 24
- Clinical observations:
- none
- Reading:
- 2nd reading
- Hours after challenge:
- 72
- Group:
- test chemical
- Dose level:
- 100%
- No. with + reactions:
- 0
- Total no. in group:
- 24
- Clinical observations:
- none
- Reading:
- 1st reading
- Group:
- negative control
- Remarks on result:
- not measured/tested
- Reading:
- 1st reading
- Group:
- positive control
- Remarks on result:
- not measured/tested
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- There were no instances of contact-sensitisation from hydratropic alcohol in this maximisation test with 24 human volunteers.
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