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EC number: 240-926-4 | CAS number: 16891-37-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- yes
- Remarks:
- , Only one concentration examined. Full detail on conditioning of solvents not reported
- GLP compliance:
- not specified
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- -0.35
- Temp.:
- 24 °C
- pH:
- 7.4
- Details on results:
- no further data
- Conclusions:
- The logPow for ethanol is -0.35
- Executive summary:
A study which followed the basic guideline principles for determination of the partition coefficient using the shake flask method measured the logPow for ethanol as -0.35 at 24°C and pH 7.4
- Endpoint:
- partition coefficient
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is inorganic
- Endpoint:
- partition coefficient
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 30th October 2019
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
- Justification for type of information:
- The test item "Magnesium diethyl dicarbonate" decomposes immediatly in contact with water. Therefore the partition coefficient was calculated by EPI Suite 4.11 (KOWWIN v. 1.68).
- Qualifier:
- according to guideline
- Guideline:
- other: Epi Suite Calculation
- Version / remarks:
- EPI Suite 4.11, KOWWIN v1.68
- Principles of method if other than guideline:
- Method: other, calculated with EPI Suite Version 4.11
- GLP compliance:
- no
- Type of method:
- other: calculation
- Remarks:
- EPI Suite Version 4.11
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- -0.67
- Temp.:
- 25 °C
- Remarks on result:
- other: QSAR
- Remarks:
- EPI Suite Version 4.11
- Conclusions:
- The calculated value of log Pow is -0.67 (calculated water solubility at 25 deg C (mg/L): 1.6e5). However, this is only a theoretical value, because the compound decomposes immediately upon contact with water (see also 5.1.2 Hydrolysis)..
Referenceopen allclose all
Description of key information
In the presence of water, magnesium diethyl dicarbonate decomposes hydrolytically very rapidly via magnesium ethanolate forming carbon dioxide, ethanol and magnesium hydroxide. See also IUCLID chapter 5.1.2 "Hydrolysis". In all experiments the hydrolysis of magnesium diethyl dicarbonate in buffer solutions (pH4, pH7, pH9) takes place immediately. Hydrolysis rates of >= 99% within 1 minute reaction time are observed.
As key information and for the chemical safety assessment the LogPow of the hydrolysis product ethanol (-0.35) is used. A low logKow of magnesium diethyl dicarbonate was predicted by QSAR according to EPI Suite 4.11 (KOWWIN v. 1.68) and the data are used as supporting data. The predicted LogKow is -0.67 at 25°C. For magnesium hydroxide as an inorganic substance no logPow can be determined.
Based on the available data it can be considered that magnesium diethyl dicarbonate and its hydrolysis products ethanol and magnesium hydroxide have a low potential for bioaccumulation.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.35
- at the temperature of:
- 24 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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