Registration Dossier
Registration Dossier
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EC number: 620-313-1 | CAS number: 877179-03-8
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according EU/OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.11 (Biodegradation: Activated Sludge Respiration Inhibition Test)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- N-{3',4'-dichloro-5-fluoro-[1,1'-biphenyl]-2-yl}acetamide
- EC Number:
- 620-313-1
- Cas Number:
- 877179-03-8
- Molecular formula:
- C14H10Cl2FNO
- IUPAC Name:
- N-{3',4'-dichloro-5-fluoro-[1,1'-biphenyl]-2-yl}acetamide
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- other: activated sludge, domestic (adaptation not specified)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 3 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- EC10
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
Applicant's summary and conclusion
- Executive summary:
A study was performed to assess the toxicity of the test substance to bacteria.
The study was conducted in accordance with Council Regulation (EC) No 440/2008, Method C.11 "Activated sludge respiration inhibition" (2008). This test method is equal to OECD Guideline 209 (1984).
The activated sludge was exposed to the test substance at different concentrations. The respiration rate of each mixture was
determined after aeration periods of 3 hours.
The test substance showed 0.0 % respiration inhibition of activated sludge at a test item concentration of 1000 mg/L.
The EC50 is higher than 1000 mg/L.
The effect value relates to nominal concentration, since no analytical monitoring was performed
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