Registration Dossier
Registration Dossier
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EC number: 603-314-1 | CAS number: 129050-23-3
Flash point
Administrative data
- Endpoint:
- flash point of flammable liquids
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7 March - 16 September 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.9 (Flash-Point)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO 2719 (Determination of flash point - Pensky-Martens closed cup method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO 3679 (Determination of flash point - Rapid equilibrium closed cup method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ASTM D93 (Standard test methods for flash point by pensky-martens closed cup tester)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: ASTM D7094: “Standard Test Method for Flash Point by Modified Continuously Closed Cup (MCCCFP) Tester”
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: UN no. ST/SG/AC.10/11/Rev.6: “Non-Viscous Flammable Liquids”
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- closed cup
- Flash point apparatus:
- other: Eraflash flash-point tester
Test material
- Reference substance name:
- (2S)-6-fluoro-2-[(2S)-oxiran-2-yl]chromane [S-(R*,R*)]
- EC Number:
- 603-314-1
- Cas Number:
- 129050-23-3
- Molecular formula:
- C11H11FO2
- IUPAC Name:
- (2S)-6-fluoro-2-[(2S)-oxiran-2-yl]chromane [S-(R*,R*)]
- Test material form:
- liquid: viscous
- Details on test material:
- - Physical state: liquid (viscous)
- Appearance: clear viscous liquid
Constituent 1
- Specific details on test material used for the study:
- - Batch n°: I16DB1991
- Analytical purity: 81.4 - 81.8%
- Expiration date: 7 June 2018
- Storage condition: at room temperature
Results and discussion
Flash point
- Key result
- Flash point:
- 20 °C
- Atm. press.:
- 1 013.25 hPa
Any other information on results incl. tables
Preliminary test
The estimated flash-point of the test item was 26°C.
Main test
The results of the main study are shown below. The difference between the results obtained with the 2 tests was =<2°C. From this it was concuded that the flash-point of the test item is the lowest flash-point obtained.
| Test | Flash-point (°C) | Lowest flash-point (°C) |
| 1 | 25 | 23 |
| 2 | 23 |
Equilibrium method
The results of the equilibrium method (tests with 5°C and tests with 1°C interval) are shown below
| Test | Expected flash-point (°C) | Result |
| 1 | 23 | Flash |
| 2 | 18 | No flash |
| Test | Expected flash-point (°C) | Result |
| 1 | 19 | No flash |
| 2 | 18 | Flash |
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (highly flammable liquids) based on GHS criteria
- Conclusions:
- The closed cup method was applied for the determination of the flash-point of JNJ-17337073-AAA (T001598).
The flash-point of the test item was 23°C based on the Pensky-Martens closed cup method.
Since the flash-point of the test item was in the range 23°C ± 2°C the equilibrium method was used. The flash-point of the test item obtained with the equilibrium method was 20°C.
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