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EC number: 403-140-4 | CAS number: 103694-68-4 MAJANTOL; MAJANTOL R
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987-05-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 1981
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-(2,2-dimethyl-3-hydroxypropyl)toluene
- EC Number:
- 403-140-4
- EC Name:
- 3-(2,2-dimethyl-3-hydroxypropyl)toluene
- Cas Number:
- 103694-68-4
- Molecular formula:
- C12H18O
- IUPAC Name:
- 2,2-dimethyl-3-(3-methylphenyl)propan-1-ol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Females nulliparous and non-pregnant: not specified
- Age at study initiation: not specified
- Weight at study initiation: males: 1.94 - 2.25 kg; females: 1.86 - 2.25 kg
- Fasting period before study: not specified
- Housing: single housing
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 7 days at least
ENVIRONMENTAL CONDITIONS
- Temperature: 18 +/- 2 °C
- Humidity: 50 - 85 %
- Photoperiod: 12 / 12 hrs dark / hrs light
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back
- Type of wrap used: gauze pads, several wrappings of "Elastoplast" and "Stülpa"
REMOVAL OF TEST SUBSTANCE
- Washing: removal with wet disposable gauze
- Time after start of exposure: 24 h after administration
TEST MATERIAL
- Amount applied: 5 mL / kg bw
- Concentration: pure - Duration of exposure:
- 24 h
- Doses:
- 5 mL / kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily observations, weighing on day 0, 7, and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, skin alterations
Results and discussion
- Preliminary study:
- Two female rabbits were employed in a preliminary range finding study. The dosage of the single dermal administration was 5.0 mL/kg. This preliminary study showed no mortalities.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 mL/kg bw
- Remarks on result:
- other: corresponding to 4985 mg/kg bw
- Mortality:
- Male: 5 mL/kg bw (ca. 4985 mg/kg bw); Number of animals: 5; Number of deaths: 0
Female: 5 mL/kg bw (ca. 4985 mg/kg bw); Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: None
- Gross pathology:
- Necropsies performed on all animals at termination exhibited no gross pathological findings.
- Other findings:
- Skin alterations:
The test item induced in all animals on the treated areas obvious erythema and edema. The symptoms described were observed in the same increased intensity during the first two days p.a. From the third day p. a. the symptoms diminished and from the 7th day p.a. 9 of 10 treated animals were without specific findings on the treated areas. One animal showed during the entire observation period fissures on the treated areas.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results of this study, the acute dermal LD50 of the test item in the rabbit was determined to be greater than 5 mL/kg bw, corresponding to 4985 mg/kg bw.
- Executive summary:
The acute dermal toxicity of the test item was investigated in two groups of 5 male and 5 female rabbits of the White New Zealand strain. Any signs of reaction were recorded during the 14-day observation period. On the treated areas the sample caused erythema and edemas. Post-dosing weight gains (2 week values) of all animals did not show essential differences. No mortalities were observed. Nothing abnormal was found in the animals necropsied on day 14. The determination of the dermal LD50 showed the following result:
24 h + 14 days
Male/female dermal LD50 > 5.0 mL/kg bw (corresponding to 4985 mg/kg bw)
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