Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 617-116-8 | CAS number: 80573-04-2
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 May - 25 May 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- - Test material: Balsalazide acid
- Batch number: 0400
- Expiry date: April 2019
- Purity: >98%
- Storage: Room temperature
- Stability: 12 months - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1
- Temp.:
- 25 °C
- pH:
- 7.5
- Details on results:
- The calibration reference standards consist of 6 reference standards of known log Pow (4-acetylpyridine, aniline, benzyl alcohol, benzonitrile, acetophenone and cinnamyl alcohol). The standards chosen had a log Pow between 0.5 and 1.9.
- Conclusions:
- The partition coefficient (n-octanol/ water, log Pow) of Balsalazide acid was found to be 1.00.
Reference
Table 1: Calibration line of the reference standards
Linear correlation: |
|
Slope |
1.5114 |
Intercept |
0.5072 |
Correlation |
0.9929 |
R2 |
0.9853 |
Table 2: Results of log Pow of the test item at pH 7.5
Average log Pow |
1.00 |
Agreement (S1-S2) |
0.0002 |
Description of key information
The partition coefficient (n-octanol/ water, log Pow) of the test item, Balsalazide acid was determined according to OECD Guideline 117 and was found to be 1.00.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
