Registration Dossier
Registration Dossier
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EC number: 296-575-2 | CAS number: 92797-39-2 Substance obtained by acidic, alkaline, or enzymatic hydrolysis of milk composed primarily of amino acids, peptides, and proteins. It may contain impurities consisting chiefly of carbohydrates and lipids along with smaller quantities of miscellaneous organic substances of biological origin.
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- n the absence of an algal inhibition study for the target substance, and in order to address the endpoint
requirement for Annex VII ECHA dossier submission for yogurtene, it is proposed to use (Q)SAR results in a weight of evidence approach.
Two well-established software tools have been used, ECOSAR and OECD QSAR Toolbox.
ECOSAR is a collection of QSAR models estimating aquatic toxicity, including short-term and long-term
toxicity to Algae. The ECOSAR models and underlying methodology have been developed over a period
of more than 25 years by EPA/OPPT (EPA, 2012). Most of the models are based on the relationship
between log Kow and toxicity (LC50 or EC50) and take into account different structural classes.
The OECD QSAR toolbox incorporates information and tools from various sources and is intended to be
used in filling gaps in (eco)toxicity data needed for assessing the hazards of chemicals. Acute aquatic
toxicity effects are the most data-rich endpoints and strategies for grouping chemicals to fill data gaps
to assess acute aquatic toxicity endpoints have been established (OECD, 2013).
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)
Test material
- Reference substance name:
- Protein hydrolyzates, milk
- EC Number:
- 296-575-2
- EC Name:
- Protein hydrolyzates, milk
- Cas Number:
- 92797-39-2
- IUPAC Name:
- Protein hydrolyzates, milk
- Test material form:
- solid
Constituent 1
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 320 mg/L
- Conc. based on:
- test mat.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- 320 mg/L
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
