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EC number: 816-856-0 | CAS number: 5205-01-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-01-14 to 2016-02-10 (experiment start-end)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Version / remarks:
- (2001)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- 3-methyl-1,3-butanediol-1-ethylate
- EC Number:
- 816-856-0
- Cas Number:
- 5205-01-6
- Molecular formula:
- C7H14O3
- IUPAC Name:
- 3-methyl-1,3-butanediol-1-ethylate
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No. of test material: Kuraray Co. Ltd. IPDA-63313
- Expiration date of the lot/batch: 30 March 2016
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature, in the dark under nitrogen
- Stability under test conditions: not stated
- Solubility and stability of the test substance in the solvent/vehicle: not stated
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: none
- Preliminary purification step (if any): n/a
- Final dilution of a dissolved solid, stock liquid or gel: one dose formulation prepared at 30 mg/mL. To achieve a 200 mg/mL dose, the test article was used as supplied
- Final preparation of a solid: n/a
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Envigo RMS (UK) Limited, Oxon
- Females nulliparous and non-pregnant: yes
- Age at study initiation: 8-12 wks
- Weight at study initiation:
- Fasting period before dosing: overnight, followed by 3-4 h post dosing
- Housing: gp housed (up to 4/cage)
- Diet (e.g. ad libitum): 2014 Teklad Global Rodent diet, ad libitum
- Water (e.g. ad libitum): municpal water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-25
- Humidity (%): 30-70
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To: 14 January 2016 to 10 February 2016
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 30 mg/mL
- Amount of vehicle (if gavage): dose volume 10 mL
- Justification for choice of vehicle: suitable vehicle for oral gavage studies
- Lot/batch no. (if required): not stated
- Purity: n/a
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: a starting dose of 300 mg/kg bw was used in the sighting study as recommended by the OECD TG 420 - Doses:
- 300 mg/kg bw
2000 mg/kg bw - No. of animals per sex per dose:
- 300 mg/kg bw: 1 females
2000 mg/kg bw: 5 females - Control animals:
- no
- Details on study design:
- The test article was dissolved in water and administered to a single female fasted Wistar rat/dose level by oral gavage at a dose levels of 300 or 2000 mg/kg bw in an initial sighting study. Animals dosed at 2000 mg/kg bw received the test article as supplied by the Sponsor, without vehicle. A further four female rats were dose orally via gavage at 2000 mg/kg bw, employing a dose volume of 10 mL/kg bw. The observation period was 14 d post dosing, with gross pathology undertaken for all animals.
- Statistics:
- None
Results and discussion
- Preliminary study:
- A sighting study was undertaken, where a single female rat was dosed, orally via gavage at 300 mg/kg bw.
No mortality, or signs of clinical toxicity were observed.
The single animal treated showed expected body weight gains over the observation period.
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: No signs of clinical toxicity were observed
- Gross pathology:
- No macroscopic changes were observed
- Other findings:
- Histopathology and organ weights not undertaken
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Under the conditions of this study the rat acute oral LD50 was >2000 mg/kg bw. Therefore, according to Annex I for Regulation (EC) 1272/2008 the formulation has no obligatory labelling requirement for acute oral toxicity and is unclassified.
- Executive summary:
Animals selected for the study were randomised by weight and group allocated. The method used to investigate the acute oral toxicity of 3 -methyl-1,3 -butanediol acetate was the acute oral fixed procedure (OECD 420 (2001)), conducted under GLP.The test article was dissolved in water and administered to a single female fasted Wistar rat/dose level by oral gavage at a dose levels of 300 or 2000 mg/kg bw in an initial sighting study. Animals dosed at 2000 mg/kg bw received the test article as supplied by the Sponsor, without vehicle. A further four female rats were dose orally via gavage at 2000 mg/kg bw, employing a dose volume of 10 mL/kg bw. The observation period was 14 d post dosing, with gross pathology undertaken for all animals.
No clinical signs of toxicity or mortality were observed in rats in the sighting or main study. Body weight gain of these animals was normal. No treatment related gross pathological findings were noted in the animals.
Under the conditions of this study the rat acute oral LD50 was >2000 mg/kg bw. Therefore, according to Annex I for Regulation (EC) 1272/2008 the formulation has no obligatory labelling requirement for acute oral toxicity and is unclassified.
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