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EC number: 819-558-9 | CAS number: 2020359-04-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1-(9,9-dibutyl-9H-fluoren-2-yl)-2-methyl-2-(morpholin-4-yl)propan-1-one
- EC Number:
- 819-558-9
- Cas Number:
- 2020359-04-8
- Molecular formula:
- C29H39NO2
- IUPAC Name:
- 1-(9,9-dibutyl-9H-fluoren-2-yl)-2-methyl-2-(morpholin-4-yl)propan-1-one
- Test material form:
- solid: particulate/powder
- Details on test material:
- a off-white powdery solid, without irritating odor
Constituent 1
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- This study was conducted semi-static system. Preparation method of test solution was calculated from the purity of 99.84 %.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Fish(Zebrafish, Danio rerio) has been used in freshwater toxicity studies, and a large comparable historical database exists; therefore, it was selected for this study.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Remarks on exposure duration:
- Fish in the treatment groups and control group were observed for general symptoms at 3, 6, 24, 48, 72 and 96 hrs after exposure and the mortality was recorded.
Test conditions
- Test temperature:
- 21.7 ~ 22.4 °C
- pH:
- 7.67 ~ 7.93
- Dissolved oxygen:
- 8.37 ~ 8.63 mg/L(94.5 ~ 97.4 %)
- Nominal and measured concentrations:
- 10.0 and 100.0 mg/L.
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 0.006 mg/L
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 0.006 mg/L
- Details on results:
- Based on the range finding test, limit test was performed in control, 100.0 mg/L nominal concentration. As a result of the stability test, concentration of the test substance(Purity: 99.84 %) in the test solution was carried out 100.0 mg/L. The measured concentrations of the test substance at the 100.0 mg/L were 0.00631 mg/L at 0 hr, 0.00653 mg/L at 48 hrs, 0.00151 mg/L at 96 hrs, based on 0 hr the test substance was not stable at 96 hrs to 23.9 %, so limit test was conducted with semi-static system. As a result of the limit test, The geometric mean of measured concentration of the test substance at the 100.0 mg/L was 0.00604 mg/L for 96 hrs. These result was 0.00604 % about nominal concentration. Therefore, all test results were
determined based on the geometric mean measured concentration.
At 96 hrs after exposure, the total mean size and weight of negative control fish were 2.8 ± 0.1 cm and 0.153 ± 0.030 g(mean±SD), respectively. treatment group fish were 2.8 ± 0.1 cm and 0.155 ± 0.029 g(mean±SD), respectively.
During the exposure period, the water temperature, dissolved oxygen concentration and pH value of test solution were in the ranges of 22.1 ~ 22.8 °C, 6.80 ~ 8.76 mg/L(converted to air saturation value: 77.4 ~ 100.2 %) and 7.37 ~ 8.07, respectively. These values were within the permissible ranges of this study.
LC50 was calculated based on the geometric means measured concentration.
Applicant's summary and conclusion
- Conclusions:
- During an exposure period, The LC50 was determined to be > 0.00604 mg/L at 48, 96 hrs after exposure. The highest concentration causing no mortality was determined to be ≥ 0.00604 mg/L at 48 and 96 hrs after exposure, respectively. The lowest concentration causing 100 % mortality was determined to be > 0.00604 mg/L at 48 and 96 hrs after exposure, respectively.
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