Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 429-320-2 | CAS number: 24748-23-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07-2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: study is done under GLP and considered complete
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- All test solutions were prepared separately. Specific loading rates of the test substance were added to M7 medium and stirred for 48 hours. The resulting mixtures were stabilized for 24 hours in a separation funnel after which the Water Accommodated Fractions (WAFs) were
obtained using the drain cock. - Test organisms (species):
- Daphnia magna
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Details on test conditions:
- The reproduction test was performed in closed vessels in a semi-static system. It included 10 vessels per test concentration and 20 vessels for an untreated control group. Each of the vessels contained one neonate «24h old) Daphnia magna in 50 ml test medium. The nominal
concentrations of Trigonox 301 tested were 1.0, 1.8, 3.2, 5.6 and 10 mg/L. The study duration was 21 days and the test solutions were renewed every 48 hours. The daphnids were fed on a daily basis with a Chtorella pyrenoidosa suspension. - Duration:
- 21 d
- Dose descriptor:
- EC10
- Effect conc.:
- 3.1 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 21 d
- Dose descriptor:
- EC10
- Effect conc.:
- > 2.7 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Details on results:
- Two out of the twenty parental daphnids in the control died during the test period. Mortality in the Trigonox 301 treatments of 0.93, 1.8 and 2.7 mg/l was comparable to or lower than the control and not statistically significant. 90-100% of the daphnids exposed to 4.9 and 8.3 mg/L, respectively, died during the test. Hence, the mortality of the parental daphnids was clearly treatment related and followed a very steep dose curve.
- Validity criteria fulfilled:
- yes
- Conclusions:
- study is complete and valid
Reference
The average cumulative number of young per female in the control after 21 days was 120 ± 13. The reproduction curve recorded at 0.93, 1.8 and 2.7 mgtl closely followed or was even slightly above the curve of the control. The curves recorded at the higher concentrations clearly stayed behind from the beginning of reproduction. Since these higher concentrations of 4.9 and 8.3 mg/L showed a high mortality number of parental organisms no final judgement regarding reproduction was possible. There were no recordings of unhatched (aborted) eggs at any of the test concentrations throughout the 21-day test period. Immobile young were only recorded at 4.9 mg/L.
Description of key information
One OECD 211 GLP test is available with an overall NOEC of 2.7 mg/L (mean measured concentration)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2.7 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.