Ammonium tetrafluoroborate

Repeated dose toxicity: oral

Administrative data

Endpoint:

repeated dose toxicity: oral, other

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Justification for type of information:

Following daily oral intake of 6.4 mg sodium tetrafluoroborate by a volunteer for a period of 14 days, a daily average of 100% was excreted in the urine and 1.6% in the feces. The fluoride content of the volunteer's food was not determined. Sodium fluoroborate is therefore well absorbed, but the fluoride which enters the body is not stored. The authors attributed this to slow hydrolysis of the tetrafluoroborate ion. In another study with 3 volunteers and a study duration of 7 to 38 weeks, there were indications that fluoride which was absorbed in the form of sodium tetrafluoroborate was stored in the body. The amount was <10% of that absorbed into the bloodstream. In addition, as a comparison and another read-across: LD50 (oral) for potassium tetrafluoroborate = 5855 mg/kg (rat).

Cross-reference

Reason / purpose for cross-reference:

read-across: supporting information

Reference

Name:

Ammonium tetrafluoroborate

Type of composition:

boundary composition of the substance

State / form:

solid: particulate/powder

Reference substance:

Ammonium tetrafluoroborate

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Materials and methods

Administration / exposure

Details on oral exposure:

Following daily oral intake of 6.4 mg sodium tetrafluoroborate by a volunteer for a period of 14 days, a daily average of 100% was excreted in the urine and 1.6% in the feces. The fluoride content of the volunteer's food was not determined. Sodium fluoroborate is therefore well absorbed, but the fluoride which enters the body is not stored. The authors attributed this to slow hydrolysis of the tetrafluoroborate ion. In another study with 3 volunteers and a study duration of 7 to 38 weeks, there were indications that fluoride which was absorbed in the form of sodium tetrafluoroborate was stored in the body. The amount was <10% of that absorbed into the bloodstream.