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Diss Factsheets
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EC number: 208-883-6 | CAS number: 544-92-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- yes
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- Since the LLNA is the preferred method for new in vivo testing, the use of the standard guinea pig tests to obtain new data on the skin sensitisation potential of a substance will be acceptable only in exceptional circumstances and will require scientific justification. However, existing data of good quality that were generated before 10 May 2017, or for which the study was initiated before 10 May 2017, and derived from such tests are acceptable. Here, the study has begun by the end of year 2016.
Test material
- Reference substance name:
- Copper cyanide
- EC Number:
- 208-883-6
- EC Name:
- Copper cyanide
- Cas Number:
- 544-92-3
- Molecular formula:
- CCuN
- IUPAC Name:
- λ¹-copper(1+) iminomethanide
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, occlusive
- Vehicle:
- water
- Concentration / amount:
- 64%
- Day(s)/duration:
- 6 hours 3 times with a 1 week interval
Challenge
- Route:
- epicutaneous, occlusive
- Vehicle:
- water
- Concentration / amount:
- 64%
- Day(s)/duration:
- 6 hours
- No. of animals per dose:
- 20 animals for the test article treatment group
10 animals/control groups (vehicle and positive control groups) - Positive control substance(s):
- yes
- Remarks:
- DNCB
Results and discussion
- Positive control results:
- In all animals of positive control group, discrete or patchy erythema (grade 1), moderate and confluent erythema (grade 2) or intense erythema and swelling (grade 3) were observed, and the sensitization rate was 100 %. Therefore, sensitization potential of positive control group fell in the category of ‘very strong (grade V)'.
In vivo (non-LLNA)
Results
- Key result
- Group:
- test chemical
- Dose level:
- 64%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- There were no test article-related abnormal clinical signs.
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- There were no test article-related clinical signs or abnormal body weight changes, and no skin reactions were recorded for the vehicle control group and the test article-treated group.
On the other hand, in positive control group, erythema was observed and the sensitization rate was 100 %. Therefore, sensitization potential of positive control group fell in the category of ‘very strong (grade V)'.
Based on the above results, under present experimental conditions, no dead animals, test article-related abnormal clinical signs or body weight changes were observed, and the sensitization rate was 0 % in the test article treatment group. Therefore, the sensitization potential of Copper cyanide (Copper(I) cyanide) was very weak (grade I).
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