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EC number: 819-688-6 | CAS number: 219828-90-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22nd August 2018 - 13th October 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- methyl 2-[(prop-2-en-1-yloxy)methyl]prop-2-enoate
- EC Number:
- 819-688-6
- Cas Number:
- 219828-90-7
- Molecular formula:
- C8H12O3
- IUPAC Name:
- methyl 2-[(prop-2-en-1-yloxy)methyl]prop-2-enoate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Animal breeding facility. Jai Research Foundataion.
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: 9-11weeks
- Weight at study initiation: Male: 311.3g - 377.3g Female: 172.9g - 215.7g
- Fasting period before study: Not specified.
- Housing: Maximum 3 rats of same sex/cage.
- Historical data:
- Diet (e.g. ad libitum): Ad libitum.
- Water (e.g. ad libitum): Ad libitum.
- Acclimation period: 7 to 9 days. Rats were also acclimatised for a period of 4h one day prior to exposure in the rat restrainer tubes.
- Method of randomisation in assigning animals to test and control groups: The censored randomization method. (Gad and Weil, 1994)
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 to 23°C
- Humidity (%): 55 to 66%
- Air changes (per hr): Minimum 15 air changes per hour.
- Photoperiod (hrs dark / hrs light): 12 hours light and 12 hours dark maintained by an automatic timer.
IN-LIFE DATES: 22nd August 2018 - 13th October 2018
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- clean air
- Mass median aerodynamic diameter (MMAD):
- >= 1 - <= 4 other: microns
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Inhalation Chamber.
- Exposure chamber volume: 2.062 Liters
- Method of holding animals in test chamber: Restraint tubes.
- Source and rate of air (airflow): Dynamic air flow rate of 12 air changes per hour and ensure adequate oxygen content of at least 19%.
- System of generating particulates/aerosols: The test item will be aerolized with the help of a spray atomizer or aerosol generator.
- Method of particle size determination: Particle size analysis will be carried out using a cascade impactor by the gravimetric method.
- Temperature, humidity, pressure in air chamber: 22°C. humidity between 30 and 70%.
TEST ATMOSPHERE
- Brief description of analytical method and equipment used: Gravimetric method.
- Samples taken from breathing zone: yes
TEST ATMOSPHERE (if not tabulated)
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): 1-4microns
CLASS METHOD (if applicable)
- Rationale for the selection of the starting concentration: Initial a study conducted with three male and three female rats. 100% mortality was observed in exposed rats at the breathing zone concentration of 5.276mg a.i/Lair, it was considered a sighting study. The full study was then conducted at three dose levels 2.407, 2.17 and 0.829 mg a.i/L air. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Breathing zone concentrations were 2.407, 2.107 and 0.829 mg a.i/L air.
- No. of animals per sex per dose:
- Three groups of rats, consisting of five males and five females per group used in the main study.
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Twice a day.
- Necropsy of survivors performed: yes
- Clinical signs including body weight
- Other examinations performed: clinical signs, body weight, organ weights, histopathology
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 1.087 mg/L air
- Based on:
- test mat.
- 95% CL:
- > 0.776 - <= 1.523
- Exp. duration:
- 4 h
- Remarks on result:
- other: This is a calculated value. Due to a mortality pattern observed, determination of a separate LC50 value for male and female rats was not possible.
- Mortality:
- Percent mortalities (both sexes combine) were observed 100, 90 and 30 at the breathing zone concentrations 2.407, 2.17 and 0.829 mg a.i/L air respectively.
- Clinical signs:
- lethargy (hypoactivity)
- Body weight:
- In groups 2 and 3 a decrease in body weight was noted however increased at day 14 when compared to Body weight on day 0.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Percent mortalities (both sexes combine) were observed 100, 90 and 30 at the breathing zone concentrations 2.407, 2.17 and 0.829 mg a.i/L air respectively.
Based on the results of this study, an indication of the classification for FX-AO-MA is as follows:
Category 4: H332: Harmful if inhaled
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