Registration Dossier
Registration Dossier
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EC number: 203-208-1 | CAS number: 104-50-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Octan-4-olide
- EC Number:
- 203-208-1
- EC Name:
- Octan-4-olide
- Cas Number:
- 104-50-7
- Molecular formula:
- C8H14O2
- IUPAC Name:
- octan-4-olide
Constituent 1
Test animals
- Species:
- rabbit
Administration / exposure
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 animals
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortalities were obesrved.
- Clinical signs:
- Diarrhea was observed in 2/10 rabbits.
- Other findings:
- Skin irritation:
Slight redness was observed in 4/10 rabbits.
Moderate redness was observed in 5/10 rabbits
Slight edema was observed in 3/10 rabbits
Moderate edema was observed in 5/10 rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute dermal toxicitiy study in rabbits, the LD50 for octan-4-olide was >5000 mg/kg bw.
- Executive summary:
In an acute dermal toxicity study (1778), 10 rabbits were given octan-4-olide at doses of 5000 mg/kg bw.
No mortalities were observed and diarrhea was observed in 2/10 rabbits. Slight redness was observed in 4/10 rabbits and moderate redness was observed in 5/10 rabbits. Slight edema was observed in 3/10 rabbits and moderate edema was observed in 5/10 rabbits.
The LD50 was > 5000 mg/kg bw.
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