Decanoic acid, mixed esters with heptanoic acid, isovaleric acid, octanoic acid and pentaerythritol

PBT assessment

PBT assessment: overall result

Reference

Name:

Decanoic acid, mixed esters with heptanoic acid, isovaleric acid, octanoic acid and pentaerythritol

Type of composition:

legal entity composition of the substance

State / form:

liquid

Reference substance:

Decanoic acid, mixed esters with heptanoic acid, isovaleric acid, octanoic acid and pentaerythritol

Reference substance:

Decanoic acid, mixed esters with heptanoic acid, isovaleric acid, octanoic acid and pentaerythritol

Reference substance:

Decanoic acid, mixed esters with heptanoic acid, isovaleric acid, octanoic acid and pentaerythritol

PBT status:

the substance is not PBT / vPvB

Justification:

Assessment of PBT / vPvB properties has been conducted in accordance with the guidance provided in Annex XIII of Regulation 1907/2006 (as amended by Commission Regulation No 253-2011 of 15 March 2011). The substance is not considered to be a PBT or a vPvB substance.

Persistence

The test substance was determined to be readily biodegradable (78 % degradation in 28 days) in a study conducted to OECD 301B and EU C.4-C test guidelines. On the basis of this result the substance is not considered to be persistent/very persistent.

Bioaccumulation

The substance has a high Kow value (6.5) which was determined experimentally using OECD test guideline 117 and EU method A.24. In accordance with the screening criteria for bioaccumulation in the ECHA guidance (Chapter R.11 PBT Assessment) the substance would screen as a potential bioaccumulative substance. The likely reliability of the log Kow is however, considered to diminish above a value of 6, as noted in Appendix R.11-1 Annex 1 of ECHA guidance on PBT assessment. Substances with log Kow between 4.5 and 6 are considered likely to be highly accumulating; however no substantial bioconcentration is assumed having a log Kow value greater than 6. For compounds having a log Kow greater than 6, a gradual decrease of BCF is observed and it has been hypothesised within the published literature that a high log Kow is more an effect of solubility than a tendency of the substance to be lipophilic. On the basis of this the substance is not considered to be bioaccumulative.

Toxicity

The substance is not considered to be toxic on the basis of the available ecotoxicity studies available:

Brachydanio rerio: 96 h LL50 > 1000 mg/L (WAF) (mortality)

Desmodesmus subspicatus: 72 h NOEC 10 mg/L; LC50 > 100 mg/L (growth rate, yield) (Read across CAS 11138-60-6)

Daphnia magna: 48 h NOEC 100 mg/L EC50 > 100 mg/L (mobility)

Activated sludge from sewage plan: 3h EC10 > 10000 mg/L (inhibition of respiration/respiration rate) (Read across CAS 11138-60-6)

A 90 day repeated dose toxicity study by the oral route was conducted with read-across substance decanoic acid, mixed esters with heptanoic acid, octanoic acid and trimethylolpropane at doses up to 1000 mg/kg had no effect on mortality, physical examinations, cageside observations, body weights, body weight changes, food consumption, ophthalmic examination findings, functional observational battery, locomotor activity, clinical pathology (clinical chemistry, hematology, coagulation, and urinalysis), gross pathology findings, absolute and relative organ weights, or histopathology findings. Based on these results, the no observed adverse effect level (NOAEL) of the test substance in Sprague Dawley rats following 90-day oral gavage dose is 1000 mg/kg/day, the highest dose level tested.

In vitro chromosome aberration test with 2,2-bis[(octanoyloxy)methyl]butyl decanoate (CAS 11138-60-6) provided negative results for structural and numerical chromosome aberrations, with or without metabolic activation. Regardless of dose level (from 625 g/ml to as high as 5000 g/ml) and dosing regimen, the test substance was concluded to be negative for structural and numerical chromosome aberrations, with or without metabolic activation.

In an in vitro mammalian cell gene mutation study, read-across substance, fatty acids, C8-18 and C18-unsatd., esters with trimethylolpropane (CAS 85186-89-6), did not induce mutations in mouse lymphoma L5178Y cells in the absence or presence of metabolic activation. Therefore, by read-across, the test substance is considered to be non‑mutagenic.

Reproductive toxicity was assessed with oral gavage administration of decanoic acid, mixed esters with heptanoic acid, octanoic acid and trimethylolpropane at doses up to 1000 mg/kg/day from implantation through the end of gestation had no effect on maternal mortality, physical examinations, cageside observations, body weights, body weight changes, or food consumption.

There were no effects on fetal development. There was no difference between the control and treated groups in male and female fetal body weights or in external findings.

Decanoic acid, mixed esters with heptanoic acid, octanoic acid and trimethylolpropane given orally at doses up to 1000 mg/kg/day to pregnant female Sprague Dawley rats during prenatal development did not result in any adverse effects on the development of the embryo/fetus.

Based on these results, the dose levels of 100, 300, and 1000 mg/kg/day were considered appropriate for the decanoic acid, mixed esters with heptanoic acid, octanoic acid and trimethylolpropane definitive prenatal developmental toxicity study in rats.

 

No carcinogenicity studies have been conducted, however there is no evidence from the available information to suggest that the substance would be carcinogenic.

The substance is not classified as carcinogenic, mutagenic or toxic to reproduction, causing chronic toxicity or specific target organ toxicity following repeated or prolonged exposure.

The substance therefore does not meet the toxicity criterion.

Conclusions

In conclusion Decanoic acid, mixed esters with heptanoic acid, isovaleric acid, octanoic acid and pentaerythritol (CAS 68130 -51 -8) is not considered to be a PBT or vPvB substance.