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Diss Factsheets
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EC number: 609-567-4 | CAS number: 38661-72-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
In a hydrolysis study, substance analogue 1,4-H6XDI was shown to rapidly disappear when dissolved in an aqueous solution. The speed at which this happens appears to be dependent on the pH, as at pH 4 the test item could only be detected at very low concentrations within the first 30 minutes, but was completely absent at later time points, while at pH 7 and pH 9 a gradual decrease was measured. At pH 7, the concentration of 1,4-H6XDI decreased to 25% of the start concentration after 3 hours, and became undetectable after 20 hours (no measurements in between), at pH 9 the concentration decreased below 10% after approximately 2.5 hours.
These results indicate rapid hydrolysis. Since 1,4-H6XDI could not be detected, it is concluded that 1,4-H6XDI reacts with itself and/or hydrolysis/degradation products in all aquatic media, forming a complex mixture of numerous, high molecular weight products. As 1,3-H6XDI also has two N=C=O groups and a saturated ring and cis/trans isomerism is not expected to have a significant influence on reactivity, it is expected to react in a similar way when dissolved in aqueous solution (for further details, see read across document included in Section 13). This property precludes performance of a reliable adsorption/desorption study and therefore this study is waived.
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- The rationale to read across the data is attached in section 13.
- Reason / purpose for cross-reference:
- read-across source
- Preliminary study:
- not conducted
- Test performance:
- pH 4
9 sampling times from 0 h to 0.7 h. Test item (max. 0.45 mg/L) was detected in one of the samples taken at 0.13 h, at 0.20 h and at 0.28 h. No test item was detected in all other samples. This indicated fast hydrolysis that could technically not be monitored.
pH 7
16 sampling times from 0 h to 19.77 h. The concentration decreased from 9.23 mg/L (at t=0) to 2.4 mg/L (at 3.13 h) and to a concentration below the limit of detection (at t=19.77 h).
Lineair regression curve (log. rel. conc. vs time ) over the time period from 0 to 3.13 h: Y = -0.167X + 1.87 (r=0.949).
Plot of the data points and the curve: see attachment
pH 9
13 sampling times from 0 h to 2.33 h. The concentration decreased from 7.48 mg/L (at t=0) to 0.55 mg/L (at t=2.33 h).
Lineair regression curve (log. rel. conc. vs time): Y = -0.271X + 1.52 (r=0.592)
Plot of the data points and the curve: see attachment
RECOVERIES
- Recovery is the concentration analysed at t=0 relative to the nominal concentration.
- The mean (n=2) recovery at pH 7 and pH 9 was calculated (see table below).
- The mean recovery for pH 7 fell within the criterion range of 90-110%.
- The mean recovery for pH 9 fell within the acceptable range for non-labelled chemicals of 70-110%.
- The concentrations analysed in the test samples were not corrected for recovery. - Transformation products:
- not specified
- Details on hydrolysis and appearance of transformation product(s):
- no data
- pH:
- 4
- Temp.:
- 20.4 °C
- Duration:
- 0 h
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- The conc. at t=0 was below the limit of detection.
- % Recovery:
- 92
- pH:
- 7.1
- Temp.:
- 21.5 °C
- Duration:
- 0 h
- % Recovery:
- 73
- pH:
- 9
- Temp.:
- 21.3 °C
- Duration:
- 0 h
- Key result
- pH:
- 4
- Temp.:
- 20.4 °C
- Remarks on result:
- not determinable because of methodological limitations
- Key result
- pH:
- 7
- Temp.:
- 21.5 °C
- Hydrolysis rate constant:
- 0.384 h-1
- DT50:
- 2 h
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 9
- Temp.:
- 21.3 °C
- Hydrolysis rate constant:
- 0.624 h-1
- DT50:
- 1 h
- Type:
- other: see "overall remarks"
- Conclusions:
- The substance is hydrolytically unstable at pH 4, pH 7 and pH 9. The half-life time of the substance at ca. 20°C at pH 7 and pH 9 was determined to be 2 hours and 1 hour, resp. The half-life time of the substance at 20°C at pH 4 could not be determined due to fast hydrolysis. This result is read across to 1,3-H6XDI.
- Executive summary:
The hydrolysis test at pH values normally found in the environment (pH 4, 7 and 9) was performed in a GLP-compliant study according to EC C.7, OECD 111 and EPA OPPTS 835.2120. Tier 2 study was performed at room temperature (i.e 20°C). Very fast hydrolysis at pH 4 which could not be monitored. The half-life time of the substance at 20°C at pH 4 could therefore not be determined. The half-life time of the substance at ca. 20°C at pH 7 and pH 9 was determined to be 2 hours and 1 hour, respectively. This result is read across to 1,3-H6XDI.
Pseudo-first behaviour at pH 9 was not demonstrated. Taken the low coefficient of correlation of 0.592 (obtained for all logarithms of the relative concentrations against time) and the obvious high variety in data points (see attachment), it was concluded that there is no linear relationship at pH 9 between the logarithms of the relative concentrations and time. Since the model for pseudo-first order was used for calculation of the half-life time, the result should be interpreted as an estimated value.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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