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Diss Factsheets
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EC number: 272-782-3 | CAS number: 68911-68-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute Toxicity: oral
Key study
The acute oral toxicity of the test material was evaluated in accordance with the techniques specified in the Regulations for the Enforcement of the Federal Hazardous Substances Act (Revised, Federal Register, September 17, 1964). The acute oral LD50 for male albino rats was found to be 1.47 mL/kg of body weight. Confidence limits could not be calculated due to the "all or none" response. The test material is classified as harmful by ingestion.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 June 1971 to 09 September 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. Federal Hazardous Substance Act
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Specific details on test material used for the study:
- - Description: Viscous, amber liquid with an unpleasant odor
- Species:
- rat
- Strain:
- other: Albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- - Diet: Commercial pellets
- Water: Available ad libitum
- Housing: Wire mesh cages suspended above droppings - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Sample administered undiluted
- Doses:
- Doses of 1.00, 2.15, 4.64, 10.0, and 21.5 mL/kg body weight
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- All animals were observed closely for gross signs of systemic toxicity and mortality at frequent intervals during the day of dosage, and at least once daily thereafter until necropsy.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1.47 mL/kg bw
- Based on:
- test mat.
- Mortality:
- At the 1.00 mL/kg dose, none of the five rats died during the 14 days of observation. At the 2.15 mL/kg dose, two rats died on the second day and all five died by Day 8. At the 4.64 mL/kg dose, four rats died on Day 2 and fifth rat died on Day 5. At the 10.0 mL/kg and 21.5 mL/kg doses, all five rats died on Day 2 of observation.
- Clinical signs:
- other: At the 1.00 mL/kg dose, signs included excessive salivation stains in all rats and bloody-appearing stains around the nose or eyes of an occasional rat. Signs persisted through the first post-dosage day. On the second day, all rats exhibited depression,
- Gross pathology:
- Gross necropsy findings in the rats which died included external evidence of diarrhea, urine stains, excessive salivation stains and bloody-appearing stains around nose, mouth or eyes. Internal changes included congested lungs, kidneys and adrenals; cardiac region of stomach and/or intestines diffusely blanched, irritated or hemorrhagic; areas of blanched tissue "thickened"; peritoneal wall irritated and/or "wrinkled"; body fat stores depleted; and autolytic alterations.
Necropsies performed on the surviving group of rats at termination revealed no gross pathological alterations. - Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral LD50 for male albino rats was found to be 1.47 mL/kg of body weight. Confidence limits could not be calculated due to the "all or none" response. The test material is classified as harmful by ingestion.
- Executive summary:
The acute oral toxicity of the test material was evaluated in accordance with the techniques specified in the Regulations for the Enforcement of the Federal Hazardous Substances Act (Revised, Federal Register, September 17, 1964). The acute oral LD50 for male albino rats was found to be 1.47 mL/kg of body weight. Confidence limits could not be calculated due to the "all or none" response. The test material is classified as harmful by ingestion.
Reference
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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