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EC number: 701-284-5 | CAS number: 2137881-70-8
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- It is considered appropriate to address the data requirements for reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid by read-across to the available studies on structurally similar substances.
Reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid is comprised of formic acid (free) up to 59%, propylidynetrimethanol (trimethylolpropane, TMP) up to 35%, and pentaerythritol up to 19.6%.
Short-term fish toxicity studies are available on ammonium formate (which is structurally similar to formic acid), propylidynetrimethanol (trimethylolpropane, TMP), and pentaerythritol. The data requirements for reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid are addressed by read-across to ammonium formate, propylidynetrimethanol (TMP) and pentaerythritol. - Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Specific details on test material used for the study:
- Ammonium formate, propylidynetrimethanol (trimethylolpropane, TMP), and pentaerythritol are being used as a read across for 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid.
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 130 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Key data from ammonium formate study
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 g/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Key data from TMP study
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Key data from pentaerythritol study
- Details on results:
- The key data from short-term fish toxicity studies on ammonium formate, propylidynetrimethanol (trimethylolpropane, TMP), and pentaerythritol are used for weight of evidence read across to reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The short-term toxicity of the target substance, reaction mass of 2,2-bis(formyloxymethyl)propane-1,3-diyl diformate and formic acid, to fish was estimated to be 96 h LC50 = >100 mg/L, based on a worst case read-across study on pentaerithritol exposure to O. latipes.
- Executive summary:
Short-term studies are available on the acute toxicity to fish for the read-across substances ammonium formate, propylidynetrimethanol (trimethylolpropane, TMP) and pentaerythritol:
A 96 h acute toxicity test for ammonium formate was carried out using Danio rerio. The LC50 was found to be 130 mg/L.
The acute toxicity of TMP to the bleak (Alburnus alburnus) was determined in a static test with brackish water and with an exposure duration of 96 h. Six different concentrations, not further specified, were tested. The 96 h LC50 was determined to be >10,000 mg/L (as reported by Linden).
The 96 hour LC50 for Oryzias latipes exposed to pentaerythritol was observed to be >100 mg/L (the highest nominal exposure concentration tested).
Reference
Description of key information
The lowest available LC50 for acute toxicity to fish is 100 mg/l for pentaerythritol.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
Short-term studies are available on the acute toxicity to fish for the read-across substances ammonium formate, propylidynetrimethanol (trimethylolpropane, TMP) and pentaerythritol:
A 96-hour acute toxicity test for ammonium formate was carried out using Danio rerio. The LC50 was found to be 130 mg/l and the NOEC was found to be 90 mg/l.
The acute toxicity of TMP to the bleak (Alburnus alburnus) was determined in a static test with brackish water and with an exposure duration of 96 h. Six different concentrations, not further specified, were tested. The 96-h LC50 was determined to be greater than 1000 mg/L as reported by Bengtsson and > 10,000 mg/L as reported by Linden
The 96 hour LC50 for Oryzias latipes exposed to pentaerythritol was observed to be >100 mg/L (the highest nominal exposure concentration tested).
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