Registration Dossier
Registration Dossier
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EC number: 947-389-1 | CAS number: -
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
Adsorption of Mochon roh (EC 947-389-1) to the solid soil phase is not expected.
Key value for chemical safety assessment
Additional information
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of of reaction mass of 4-methoxyphenol and 4-methoxy-cyclohexanone and 4-methoxy-cyclohexanol (EC 947-389-1; Mochon roh) (Q)SAR results were used for the estimation of the adsorption potential. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, further experimental studies on the adsorption potential are not provided.
Assessment
In order to assess the adsorption potential of the substance Mochon, roh (EC 947-389-1), the Koc values were estimated using QSAR models for its three representative constituents: 4-methoxycyclohexanone (CAS 13482-23-0), 4-Methoxycyclohexan-1-ol (CAS 18068-06-9), Mequinol (CAS 150-76-5). Moreover, a GLP study with 4-methoxycyclohexanone (CAS 13482-23-0), followed by OCED guideline 121 was performed (ECHA, disseminated data, 2018). According to this study, the log Koc value was determined to be 1.2.
|
4-methoxycyclohexanone (CAS 13482-23-0), |
4-Methoxycyclohexan-1-ol (CAS 18068-06-9) |
Mequinol (CAS 150-76-5) |
KOCWIN v2.00 Kow Method |
Koc = 15.5 L/kg Log Koc = 1.2 |
Koc = 7.3 L/kg Log Koc = 0.87 |
Koc = 105 L/kg Log Koc = 2.0 |
KOCWIN v2.00 MCI Method |
Koc = 7.1 L/kg Log Koc = 0.85 |
Koc = 4.6 L/kg Log Koc = 0.66 |
Koc = 120 L/kg Log Koc = 2.1 |
| Franco & Trapp (2008/2009/2010) | no data | no data | 2.88 at pH 7 |
Based on the available experimental and calculated data from read-across, it can be concluded, that adsorption of Mochon, roh (EC 947-389-1) to the solid soil phase is not expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
