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EC number: 214-527-0 | CAS number: 1141-38-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 March 2018 - 1 June 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and batch No.of test material: Sigma Aldrich, lot No. 15021MU
- Expiration date of the lot: 30 Jan 2019
- Purity test date:
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Ambient - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products: 0 and 5 days (50ºC, pH 4, 7 and 9)
- Sampling method: 2 mL aliquot diluted with 2 ml acetonitrile
- Sampling intervals/times for pH measurements: Initial test solutions and final sampling
- Sampling intervals/times for sterility check: Initial test solutions and final sampling
- Sample storage conditions before analysis: Samples stored at <-20 ºC and analysed within 2 days of extraction. - Buffers:
- - pH: 4
- Type and final molarity of buffer: Sodium acetate 0.01 M
- Composition of buffer: Sodium acetate trihydrate dissolved in deionised water (ca 900 mL)
- pH: 7
- Type and final molarity of buffer: Tris (hydroxymethyl) aminomethane hydrochloride, 0.01 M
- Composition of buffer: Tris (hydroxymethyl) aminomethane hydrochloride dissolved in deionised water
- pH: 9
- Type and final molarity of buffer: Di-sodium tetraborate, 0.01 M
- Composition of buffer: Di-sodium tetraborate decahydrate dissolved in deionised water - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: Screw capped straight sided amber glass tubes of approximately 8 mL capacity
- Sterilisation method: Filtration of the solutions through a 0.2µm bottle top filter. Glasware was sterilised using an autoclav. Vessel caps and pipette tips were sterilitzed with ethanol:water 70:30 (v/v)
- Lighting: dark
- Measures to exclude oxygen: Bubbling with nitrogen
TEST MEDIUM
- Kind and purity of water: deionised water
- Preparation of test medium: Buffer salts were dissolved in deionized water
OTHER TEST CONDITIONS
- Adjustment of pH: Buffers were adjusted with acetic acid (pH 4), sodium hydroxide solution (pH 7) and HCl (pH9), respectively - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.03 µg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.03 µg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.03 µg/L
- Number of replicates:
- 2
- Positive controls:
- yes
- Remarks:
- Agar plates to confirm sterility
- Negative controls:
- no
- Preliminary study:
- No hydrolytical degradation was observed in the Tier 1 study. Therefore, a Tier 2 study was not conducted
- Transformation products:
- no
- Key result
- Remarks on result:
- hydrolytically stable based on preliminary test
- Details on results:
- TEST CONDITIONS
- pH, sterility, temperature, and other experimental conditions maintained throughout the study: Yes
TRANSFORMATION PRODUCTS
No degradation and hence no transformation products were observed at any of the tested pH values. - Validity criteria fulfilled:
- yes
- Conclusions:
- 2,6-Naphthalene dicarboxylic acid is hydrolytically stable under the conditions of the test.
Reference
Description of key information
2,6 -Naphthalene dicarboxylic acid is hydrolytically stable.
Key value for chemical safety assessment
Additional information
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